MODE OF ACTION OF THYMUS DERIVED (T) SUPPRESSOR AND AMPLIFIER CELLS

参与III型抗体应答的调节性T细胞 肺炎球菌多糖（SSS-III）可通过输注B而被激活 通过预先暴露于抗原（SSS-III）引发的细胞。 如果这种免疫B 细胞在转移前与适量的F（ab ′）2孵育 来自抗IgM和IgG（重链和轻链特异性）抗体的片段， 或抗IgM（链特异性）抗体，则转移的B细胞不能起作用 作为抑制性T细胞激活的诱导剂。 相比之下， 用抗IgD（δ链特异性）的F（ab '）2处理免疫B细胞 是无效的。 由于抗体处理和未处理的B细胞 在细胞转移后以相同的方式定位于脾脏，这些 研究结果表明，B细胞表面抗体的IgM类发挥作用， 在参与免疫应答的抑制性T细胞活化中的重要作用 SSS-III抗体反应。

Regulatory T cells involved in the antibody response to Type III pnuemococcal polysaccharide (SSS-III) can be activated by the infusion of B cells primed by prior exposure to antigen (SSS-III). If such immune B cells are incubated before transfer-with appropriate amounts of F(ab')2 fragments from anti-IgM and IgG (heavy and light chain specific) antibody, or anti-IgM (chain specific) antibody, the transferred B cells fail to act as inducers for the activation of suppreessor T cells. By contrast, the treatment of immune B cells with F(ab')2 of anti-IgD (delta chain specific) is without effect. Since both antibody treated and untreated B cells localized to the spleen in the same manner after cell transfer, these findings indicate that B cell surface antibody of the IgM class plays an important role in the activation of suppressor T cells involved in the antibody response to SSS-III.