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Developing functionalised microbubbles for molecular ultrasound imaging and targeted delivery of drugs and microRNA therapeutics

Developing functionalised microbubbles for molecular ultrasound imaging and targeted delivery of drugs and microRNA therapeutics
开发用于分子超声成像以及药物和 microRNA 疗法的靶向递送的功能化微泡
批准号：
nhmrc : 1050018
负责人：
Prof Karlheinz Peter
金额：
$45.16万
依托单位：
Baker IDI Heart and Diabetes Institute
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2013
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2013-01-01 至 2016-12-31
来源：
https://researchdata.edu.au/developing-functionalised-microbubbles-microrna-therapeutics/112133
关键词：
Developingfunctionalisedmicrobubblesmolecularultrasound

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中文摘要
翻译
我们的目标是开发充气微泡，这些微泡针对血栓形成和炎症的标志物，并将允许通过超声可视化血块和早期炎症反应。这将有助于早期和及时治疗。我们将在各种血栓和炎症动物模型中系统地测试用重组抗体包被微泡的最佳方法。此外，我们计划将药物装载到微泡中，并将这些药物靶向需要它们的区域。
英文摘要
We aim to develop gas-filled microbubbles that are directed to markers of thrombosis and inflammation and will allow visualisation of blood clots and early inflammatory reactions via ultrasound. This will allow early and timely treatment. We will systematically test for the best method of microbubble coating with recombinant antibodies in various animal models of thrombosis and inflammation. In addition, we plan to load microbubbles with drugs and target these to areas where they are needed.
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