Expansion of state-of-the-art MR imaging infrastructure for pulmonary disease stratification: POLARIS

POLARIS技术开发专业知识的独特组合以及在谢菲尔德大学将新技术转化为开创性临床研究的成熟能力构成了本申请资金的基础。我们与谢菲尔德的两个医院信托基金（谢菲尔德教学医院和谢菲尔德儿童医院）有着长期的高层合作，这使我们能够将我们的发展应用于所有年龄组。这使谢菲尔德成为一个国家临床转诊中心，用于基于图像的肺部疾病理解，但我们的工作也使英国境内的其他中心能够推出这些方法，使更广泛的患者群体受益。这一申请是特别及时的NIHR研究教授奖吉姆野生在2013年，这将有助于在其他中心的技术的国家吸收。通过这笔赠款，我们的气体极化设施的扩展将为我们的合作中心带来许多好处，包括为那些没有自己的极化设施的中心创建一个超极化气体的国家分配设施。正在进行的方法学研究，临床评估以及与制药公司就计划中的新的最先进的1.5T扫描仪进行的合作将确保英国成为诊断医学这一重要领域的领先国家。

Summary of POLARISThe unique combination of expertise in technology development and the proven ability to translate new technologies into pioneering clinical studies at the University of Sheffield forms the basis of this application for funding. We have long-standing high-level collaborations with both Hospital Trusts in Sheffield (Sheffield Teaching Hospital and Sheffield Children's Hospital) that allow us to apply our developments in all age groups. This has established Sheffield as a national clinical referral centre for image based understanding of lung diseases, but our work has also enabled other centres within the UK to roll out the methods for the benefit of a much wider group of patients. This application is particularly timely with the award of the NIHR Research Professorship to Jim Wild in 2013, which will facilitate the national uptake of the technology at other centres. The expansion of our gas polarisation facilities enabled by this grant will have many benefits for our collaborating centres including creation of a national distribution facility for hyperpolarised gases for those centres that don't have their own polarisation facilities. The ongoing methodological research, clinical evaluations and work with drug companies performed on the planned new state-of-the art 1.5T scanner will ensure that the UK becomes the leading nation in this important area of diagnostic medicine.