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A new paradigm for the control of cellular function: the dynamic reshaping of the epigenome by histone variants

A new paradigm for the control of cellular function: the dynamic reshaping of the epigenome by histone variants
控制细胞功能的新范例:组蛋白变体动态重塑表观基因组
批准号:
nhmrc : 1058941
负责人:
Prof David Tremethick
金额:
$44.86万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2017-12-31

项目摘要

项目成果

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中文摘要
翻译
我们的DNA被包装和分割成稳定的身份,染色体,这对正常的细胞功能和我们的遗传物质从一个细胞到下一代的遗传至关重要。染色体完整性的丧失会导致癌症,因此细胞必须确保这种情况不会发生。我们发现了一种新的机制,即染色体的不同组成部分可以动态地从一个位置移动到另一个位置,以确保染色体在受到挑战时保持稳定。
英文摘要
Our DNA is packaged and partitioned into stable identities, chromosomes, which is critical for proper cell function and the inheritance of our genetic material from one cell generation to the next. Loss of chromosome integrity leads to cancer and therefore the cell must ensure that this does not happen. We have uncovered a new mechanism whereby different components of chromosomes can dynamically move from one location to another to ensure chromosomes remain stable when they are challenged.
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会议论文
Uncovering an evolutionary advanced mechanism of gene expression control
  • 批准号:
    DP230101039
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $54.32万
  • 财政年份:
    2023
  • 负责人:
    Prof David Tremethick
  • 依托单位:
Uncovering new epigenetic-based regulatory mechanisms of gene expression: novel links between histone variants, RNA function and disease
  • 批准号:
    nhmrc : 1142399
  • 项目类别:
    Project Grants
  • 资助金额:
    $71.24万
  • 财政年份:
    2018
  • 负责人:
    Prof David Tremethick
  • 依托单位:
Dissecting a RNA-histone variant interaction and its role in splicing
  • 批准号:
    DP170102525
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $43.59万
  • 财政年份:
    2017
  • 负责人:
    Prof David Tremethick
  • 依托单位:
The special role of histone variants in regulating the inheritance and 3-dimensional organisation of the epigenome
  • 批准号:
    nhmrc : 1104340
  • 项目类别:
    Project Grants
  • 资助金额:
    $66.24万
  • 财政年份:
    2016
  • 负责人:
    Prof David Tremethick
  • 依托单位:
国内基金
海外基金
范型(Paradigm)统一化问题
  • 批准号:
    68783007
  • 项目类别:
    专项基金项目
  • 资助金额:
    3.0万元
  • 批准年份:
    1987
  • 负责人:
    林惠民
  • 依托单位: