Computer Aided Two-Dimensional Electrophoretic Gel Analy

GELLAB-II软件系统http：//www-lecb.ncifcrf.gov/lemkin/gellab.html是一种探索性数据分析系统，用于分析UNIX中编写的2D电泳蛋白质凝胶图像集。它包括用于图像采集、处理、数据库操作、图形和统计分析的复杂子系统。它已被应用于各种实验系统中，定量和定性的变化，在一个或多个蛋白质中的数百或数千个未改变的蛋白质，是基本的分析问题。跟踪使用这些方法检测到的变化也是系统的一个主要属性。可以在不同的探索性数据分析条件下查看复合凝胶数据库，并且从有效3D数据库的切片中阐明统计差异和细微模式。结果可以以各种表格、绘图或衍生图像的形式呈现，并通过广域网在工作站上呈现。GELLAB-II研究已与CSPI/Scanalytics Inc.达成技术转让CRADA，GELLAB-II+系统，使癌症研究人员可以在廉价的Microsoft Windows PC（1996年发布）上轻松使用该技术。这种商业化导致了GELLAB-II技术的更广泛的使用和更好的支持，超过了我们所能提供的。 Z01 BC 08381-16

The GELLAB-II software system, http://www-lecb.ncifcrf.gov/lemkin/gellab.html, is an exploratory data analysis system for the analysis of sets of 2D electrophoretic protein gel images written in UNIX. It incorporates sophisticated subsystems for image acquisition, processing, database manipulation, graphics and statistical analysis. It has been applied to a variety of experimental systems in which quantitative and qualitative changes, in one or more proteins among hundreds or thousands of unaltered proteins, is the basic analytic problem. Keeping track of changes detected using these methods is also a major attribute of the system. A composite gel database may be viewed under different exploratory data analysis conditions, and statistical differences and subtle patterns elucidated from slices of an effective 3D database. Results can be presented in a variety of tables, plots or derived images and on workstations over wide area networks. The GELLAB-II research has resulted in a technology transfer CRADA with CSPI/Scanalytics Inc., for a commercially available system GELLAB-II+, making this technology easily available to cancer researchers on inexpensive Microsoft Windows PCs (released in 1996). Such commercialization resulted in wider use and better support of the GELLAB-II technology than we could provide. Z01 BC 08381-16