Order Restricted Inference With Applications To Toxicolo

该项目的重点是开发新的统计方法，并应用新的和现有的统计技术，分析订单限制毒理学数据。研究的一个领域集中在测试肿瘤发生率的剂量相关趋势。开发了一种通用程序，可应用于各种问题，包括国家毒理学计划（NTP）研究中遇到的一些问题。这种新的测试比当前的（Poly-3）测试更强大，并且在剂量-反应曲线的形状、剂量对死亡率的影响、剂量之间的间隔和背景肿瘤率的大小方面具有鲁棒性。开发了类似的技术，以更有效地估计置信区间，并在数据相关时检测趋势。此外，还开发了新的方法来分析来自不同来源（例如不同实验室）的数据。

This project focuses on developing new statistical methods, and applying new and existing statistical techniques, to analyze order-restricted toxicology data. One area of research focused on tests for dose-related trends in tumor rates. A general procedure was developed which can be applied to a wide array of problems, including some of those encountered in National Toxicology Program (NTP) studies. This new test is more powerful than the current (Poly-3) test and is robust with respect to the shape of the dose-response curve, the effects of dose on mortality, the spacings between doses, and the size of the background tumor rate. Similar techniques were developed to more efficiently estimate confidence intervals and to detect trends when the data are correlated. Also, new methods were developed to analyze data from heterogeneous sources (e.g. different laboratories).