ERP and fMRI of emotion and cognition in psychopathy

描述(申请人提供)：精神病是一种由一系列人际、情感和行为特征组成的人格障碍。精神病患者对刑事和非刑事的公民骚乱负有不成比例的责任。精神病的社会成本，包括财政和情感因素，与其他类似患病率的主要精神疾病(约占总人口的1%)相媲美。然而，相对于其他主要疾病(例如精神分裂症)，人们对与精神病有关的神经认知系统知之甚少。最近由主要研究人员进行的小规模电生理和血流动力学成像研究表明，犯罪精神病与执行情绪性、错误监测和显著刺激(例如，古怪)处理任务时边缘系统的功能异常有关。受累的初级边缘旁结构包括杏仁核、眼眶额叶皮质、前上回、吻侧和尾侧前扣带回以及后扣带回。本提案的目的是在从来自不同社会经济背景的伦理不同的男性和女性的社区人口中提取样本，以检验精神变态的边缘假说。高时间分辨率电生理技术和高空间分辨率血流动力学成像将被用来绘制与情感、错误监测和显著刺激处理任务相关的功能神经结构图，这些任务根据精神病评分进行分层。拟议项目的最终目的是更全面地了解与精神病有关的大脑系统，其次是开始了解大脑功能如何与精神变态症状相关。在研究结束时，将可以获得数据来表征精神变态患者的功能障碍神经解剖学，而不是专门从监禁样本中提取。这些数据还将允许按照性别和社会经济路线检查特定于精神病的边缘旁脑功能异常，探索大脑功能异常与精神病症状亚型的关系，并将提供关于精神病与酒精和物质障碍的脑功能异常之间相互关系的数据。

DESCRIPTION (provided by applicant): Psychopathy is a personality disorder comprised of a constellation of interpersonal, affective and behavioral characteristics. Individuals with psychopathy are responsible for a disproportionate amount of civil disruption, both criminal and noncriminal. The societal cost of psychopathy, including fiscal and emotional components, rivals those of other major mental illnesses of similar prevalence (~1% general population). However, relative to other major disorders (e.g., schizophrenia), little is known about the neurocognitive systems implicated in psychopathy. Recent small scale electrophysiological and hemodynamic imaging studies done by the primary investigator have shown that criminal psychopathy is associated with functional abnormalities in the paralimbic system during performance of affective, error-monitoring, and salient stimulus (e.g., oddball) processing tasks. The primary paralimbic structures that appear to be implicated include the amygdala, orbital frontal cortex, anterior superior temporal gyrus, rostral and caudal anterior cingulate, and posterior cingulate. The purpose of the present proposal is to test the paralimbic hypothesis of psychopathy in samples drawn from community based populations of ethically diverse males and females from varied socio-economic backgrounds. High temporal resolution electrophysiological techniques and high spatial resolution hemodynamic imaging will be used to map the functional neural architecture associated with affective, error-monitoring, and salient stimulus processing tasks in groups stratified by psychopathy scores. The ultimate aim of the proposed project is to obtain a more complete understanding of the brain systems implicated in psychopathy, and secondarily, to begin to understand how brain function relates to psychopathic symptomology. At the conclusion of the study, data will be available to characterize dysfunctional neuroanatomy in psychopaths not drawn exclusively from incarcerated samples. The data also will permit an examination of psychopathy-specific paralimbic brain function abnormalities along gender and socioeconomic lines, exploration of how brain function abnormalities relate to psychopathy symptom subtypes, and will provide data on the inter-relationship of functional brain abnormalities in psychopathy and alcohol and substance disorders.