CONSTRUCTION OF SPF RHESUS MACAQUE FACILITY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。拟议中的建筑将提供一个由六座建筑组成的综合体，用于SPF印度原产恒河猴，并将它们用于与艾滋病相关的研究。养殖设施将由四栋建筑组成，每栋建筑有14个室内外笼子。这些建筑的总面积为14,864平方英尺。养殖笼被分成四栋楼，以减少疾病传播。一栋温控建筑(544平方英尺)英国《金融时报》)将与用于治疗患病动物的养殖笼舍密切相关地建造。它将有一间治疗室、一间隔离室和支援室。建筑群中剩余的建筑将是一个人事支持设施。它将包括两个更衣室、一间办公室和一间休息室(624平方米。FT.)。将在这个建筑群中安置的SPF繁殖群体由美国国立卫生研究院(NIH)合作协议(U42-RR16024)资助。根据这项合作协议，SNPRC将培育SPF猕猴，主要供NIH资助的艾滋病相关研究人员使用。SWRPRC繁殖殖民地目前由大约290只动物组成，位于距离SNPRC约20英里的一个有40年历史的建筑群中，以及一个计划于2002年移交给圣安东尼奥市的军事基地。除了远距离维护这样一个设施的运作困难外，目前的设施还无法容纳预计在未来四年内种群规模大约翻一番的情况。SNPRC结合了经验丰富的专业人员、成熟的方法和一流的设施，对用于猴免疫缺陷病毒(SIV)/艾滋病研究的SPF猕猴进行病毒学和免疫学评估。这些资源，再加上最近收购的SPF恒河猴群体和熟练掌握最先进的遗传和人口管理的工作人员，使SWRPRC在满足全国对SPF恒河猴在艾滋病相关研究中的需求方面发挥关键作用。拟议的建设将为SNPRC提供必要的动物收容所设施，以充分发挥其潜力，满足这一国家研究需求。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The proposed construction will provide a complex of six buildings to be used for SPF Indian-origin rhesus monkeys and using them in AIDS-related research. The breeding facilities will consist of four buildings each with 14 indoor-outdoor cages. Total square footage of these buildings is 14,864. The breeding cages are separated into four buildings to reduce disease transmission. A climate-controlled building (544 sq. ft.) will be constructed in close association with the breeding cage buildings to be used for treating ill animals. It will have a treatment room, an isolation room and support rooms. The remaining building in the complex will be a personnel support facility. It will include two locker rooms, an office and a break room (624 sq. ft.). The SPF breeding colony to be housed in this complex is funded by a National Institutes of Health (NIH) Cooperative Agreement (U42-RR16024). Under this cooperative agreement, the SNPRC will produce SPF rhesus monkeys for use primarily by NIH-grantees conducting AIDS-related research. The SWRPRC breeding colony, currently consisting of about 290 animals, is housed in a 40-year-old complex approximately 20 miles from the SNPRC and on a military base that is scheduled to be turned over to the City of San Antonio in 2002. In addition to the operational difficulties of maintaining such a facility from a distance, the present facility can not accommodate the approximate doubling in colony size that is expected within the next four years. The SNPRC combines experienced professional staff, proven methods, and excellent facilities for the virological and immunological evaluation of SPF rhesus macaques used in simian immunodeficiency virus (SIV)/AIDS research. These resources, combined with the recently acquired SPF rhesus colony and staff skilled in state-of-the-art genetic and demographic management, position the SWRPRC to play a pivotal role in meeting the national need for SPF rhesus in AIDS-related research. The proposed construction will provide the animal housing facilities necessary for the SNPRC to fully realize its potential to meet this national research need.