COLLAGEN ORIENTATION IN ARTICULAR CARTILAGE IMAGED WITH PS-OCT AND MPM

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。偏振敏感光学相干断层扫描(PS-OCT)通过检测关节软骨标本中组织双折射的变化，被评估为一种潜在的退行性关节疾病的诊断工具。组织的双折射既受组织的材料组成的影响，也受组织相对于光轴的组织和取向的影响。为了更好地解释关节软骨标本获得的位相延迟图像，利用非线性光学显微镜来描述PS-OCT成像的关节软骨标本中胶原纤维的组织和取向。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Polarization Sensitive Optical Coherence Tomography (PS-OCT) is being evaluated as a potential diagnostic tool for the evaluation of degenerative joint disease, by examining alterations in tissue birefringence in articular cartilage specimens. Tissue birefringence is influenced by both the material composition of the tissue and its orgainization and orientation in relation to the optical axis. Non-linear optical microscopy is being used to describe the organization and orientation of collagen fibers in articular cartilage specimens imaged by PS-OCT in order to better interpret the phase retardation images obtained from articular cartilage specimens.