NEUROENDOCRINE FACTORS IN ADOLESCENT OBESITY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。肥胖症是一种流行病，比以往任何时候都更年轻。肥胖与几种激素分泌模式的变化有关，包括生长激素释放肽、生长激素（GH）和胰岛素，这些激素在青少年年龄组中尚未被研究。Ghrelin是一种主要在胃中产生的激素，增加食欲并导致GH分泌。本研究旨在比较超重与正常体重青春期少女生长激素释放肽和生长激素分泌的变化。了解肥胖相关的生长激素释放肽和生长激素的变化及其与身体成分，胰岛素抵抗和食欲的关系将有助于制定减少肥胖并发症的策略。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity is an epidemic that is striking people at younger ages than ever before. Obesity is associated with changes in the secretory patterns of several hormones including ghrelin, growth hormone (GH), and insulin, which have not been examined in the adolescent age group. Ghrelin, a hormone produced mainly in the stomach, increases appetite and causes GH secretion. This study will compare the change in secretion of ghrelin and GH in overweight and normal weight adolescent girls. Understanding obesity-related changes in ghrelin and GH and their relationship to body composition, insulin resistance, and appetite will help in the development of strategies to reduce complications of obesity.