YOHIMBINE CHALLENGE TO STUDY NORADRENERGIC FUNCTION IN INDIVIDUALS

家庭暴力是影响社会的主要问题。结果来自我们的 研究表明，身体虐待他们的人 重要的人经常在那个时候经历一种极度兴奋的状态 以运动活动增加为特征的暴力行为， 自主神经系统活动增强，并伴有情绪 “失控”。这种过度兴奋的状态类似于 这发生在创伤后应激障碍(PTSD)中。因为PTDS已经 与去甲肾上腺素能功能的变化有关，(1)我们假设 失控和身体暴力的受试者也可能有 去甲肾上腺素功能异常。为了验证这一假设，我们设计了 一项比较行为和生化影响的研究 α-2受体拮抗剂育亨宾在患者间的应用 他们失去了控制，是身体暴力和攀比的对象。

Domestic violence is a major problem affecting society. Results from our research show that individuals who are physically abusive to their significant others frequently experience a hyperaroused state at the time of the violent act which is characterized by increased motor activity, heightened autonomic nervous system activity and accompanied by feelings of "being out of control". This hyperaroused state is similar to that which occurs in Post Traumatic Stress Disorder (PTSD). Since PTDS has been associated with changes in noradrenergic function, (1) we postulate that subjects who lose control and are physically violent may also have abnormal noradrenergic function. To test this hypothesis, we designed a study to compare the behavioral and biochemical effects resulting from the administration of the alpha-2 antagonist yohimbine between patients who lose control and are physically violent and comparison subjects.