Keystone Symposium on Chemokines and Chemokine Receptors

摘要 这项提议是请求支持题为趋化因子和趋化因子的Keystone研讨会 Receiver将于2008年1月13日至18日在科罗拉多州的Keystone举行。细胞迁移是一个关键 在动态平衡和病理条件下淋巴组织个体发生的要素，对于 白细胞对机体各室的巡逻，以及先天和适应性的激活和定位 豁免权。趋化因子是运输、定位和功能调节的主要组成部分。 正常情况下和不同病理情况下的白细胞和非造血细胞。结构分析 而成像方法使人们更好地理解了这一复杂的 调解人。趋化因子是开发创新治疗策略的主要目标，其中一些 它们正开始接受临床评估。这次会议将把科学家和临床医生聚集在一起 以不同的专业知识总结目前对趋化因子系统及其参与的理解 在人类病理学中，专注于转化为新的诊断和治疗的前景和挑战 工具。

ABSTRACT This proposal is to request support for a Keystone Symposia meeting entitled ¿Chemokines and Chemokine Receptors¿, which will be held in Keystone, Colorado from January 13 ¿ 18, 2008. Cell migration is a key element for the ontogenesis of lymphoid tissues under homeostatic and pathological conditions, for the patrolling of body compartments by leukocytes, and for the activation and orientation of innate and adaptive immunity. Chemokines are a major component of the trafficking, positioning and functional regulation of leukocytes and nonhematopoietic cells in normal conditions and in diverse pathologies. Structural analysis and imaging approaches have resulted in a better understanding of the action of this complex family of mediators. Chemokines are a prime target for the development of innovative therapeutic strategies, some of which are beginning to undergo clinical assessment. This meeting will bring together scientists and clinicians with different expertise to summarize the current understanding of the chemokine system and its involvement in human pathology, focusing on prospects and challenges for translation into new diagnostic and therapeutic tools.