NEURAL CONTROL OF VISUAL VESTIBULAR BEHAVIOR

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 正常的姿势、平衡和稳定的视力取决于视觉和前庭系统之间的相互作用。 我们的研究旨在确定正常的视觉-前庭-眼神经行为的神经基质。由于前庭系统的正常发育或损伤，一直需要校准前庭眼反射的运动输出。 如果没有这种校准，在运动过程中保持平衡和清晰的视觉将出现困难。 除了长期的校准，视觉还受到每时每刻或动态视觉-前庭相互作用的支持。 我们最近使用了一个平滑的追求和前庭测试相结合，以证明平滑的追求相关的神经元在MSTd区进行意志平滑的追求命令信号。 这与MST神经元仅携带与眼睛位置相关的传出复制或本体感受信号的论点相反。 我们现在正在完成一项研究，该研究记录了由额眼场携带到NRTP的信号。 我们的目标是确定平行的皮质-桥脑-小脑通路支持注视控制的信息。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Normal posture, balance and stable vision are dependent on interactions between the visual and vestibular systems. Our studies are directed at defining the neural substrate for normal visual-vestibular-oculomotor behavior. There is a continuous need to calibrate the motor output of the vestibular ocular reflex due to normal development or injury to the vestibular system. Without this calibration, difficulties in maintaining balance and clear vision during locomotion would occur. In addition to long-term calibration, vision is supported by moment-by-moment or dynamic visual-vestibular interactions. We recently used a combination of smooth pursuit and vestibular testing to demonstrate that smooth pursuit related neurons in area MSTd carry volitional smooth pursuit command signals. This is in contrast to the argument that MST neurons simply carry efference copy or proprioceptive signals related to eye position. We are now finishing a study that documents the signals carried by frontal eye fields to the NRTP. Our goal is to define the information carried in parallel cortical-ponto-cerebellar pathways supporting gaze control.