AGE DETERMINANT OF REPRODUCTIVE SUCCESS AMONG CAPTIVE FEMALE RHESUS MACAQUES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 对一群圈养恒河猴的生育结果进行了回顾性分析。该分析涵盖了30多年，基于1443名女性，共11453例妊娠。 对生育率的各种决定因素进行了评估，包括出生率、妊娠损失、婴儿存活率、生育间隔和最后一次生育至死亡的间隔。使用具有随机截距的广义线性模型分析二元变量，而线性混合模型用于分析连续变量。母体年龄是确定妊娠是否导致分娩以及婴儿是否存活前30天的重要因素，而经产或高龄母亲不太可能生产存活至该年龄的婴儿。相比之下，性别被证明是决定婴儿是否活到一岁的唯一重要因素，女性更有可能存活下来。出生间隔主要受年龄的影响，而婴儿的迟死则降低了她最后一次出生和死亡之间的时间间隔延长的可能性。总的来说，这些结果表明，产妇年龄对生育率下降有很大的影响，年龄较大的女性在生育最后一个婴儿后可以活得相对较长。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A retrospective analysis was performed on fertility outcomes among a colony of captive rhesus monkeys. The analysis covered over 30 years and was based on 1443 females with a total of 11453 pregnancies. Various determinants of fertility were assessed including birth rates, pregnancy loss, infant survival, interbirth intervals and interval from last birth to death. Binary variables were analyzed with generalized linear models with random intercepts, while linear mixed models were used for analysis of continuous variables. Age of the dam was a significant factor in determining whether a pregnancy resulted in a birth and whether an infant survived the first 30 days with primiparous or older mothers being less likely to produce an infant surviving to that age. In contrast, sex proved to be the only significant factor in determining whether an infant lived to one year, with females being more likely to survive. The interval between births proved to be affected primarily by dam age, while the late death of an infant depressed the likelihood of an extended time interval between her last birth and her death. Overall, these results demonstrate that maternal age contributes significantly to a decline in fertility and that older females can live relatively long periods following birth of their last infant.