Training at the Chemistry: Biology Interface

描述(由申请人提供)：化学：生物学接口的多学科研究在过去几十年中发展如此迅速，这种交叉培训现在对下一代化学家和生物学家的发展至关重要。德克萨斯A&M大学拟议的培训计划的目标是培训化学、生物化学和生物物理学系的预科研究生，以及在化学：生物接口(CBI)研究方面的生物系研究生。自1994年成立以来，这个由美国国立卫生研究院赞助的项目在我们的分子生命科学研究生的成功培训中发挥了重要作用。该项目目前涉及27名教职员工，他们的研究兴趣非常广泛，包括：a)机械酶学(Raushel)，b)大分子相互作用(Hu，Reinhart，Schultz)；c)合成(Burgess，Connell，Darensburg，Romo，Yang)；d)生物分析(Cremer，Russell，Vigh)；e)代谢(Begley，Lindahl，Watanabe)；f)结构/功能关系(Barondeau，Hilty，Sacchettini)；g)计算反应机制(Gao，Singleton)；h)时间生物学(Golden和Bell-Pederson)；i)行为生物学(Garcia)和j)化学生物学(Pellois，Liu，Ryan，Young)。这种多样性是我们CBI项目的一大优势，因为它对更广泛的学生具有吸引力，并为化学：生物界面提供更多的交叉培训。CBI项目的学生选择这些培训师中的一位作为他们的主要研究顾问，并参加一组核心的必修课，其中重点是数量生物学的培训。CBI的学生参加每周一次的期刊俱乐部，在那里讨论这一领域的研究主题，强调与人类健康、生理学和疾病的联系。学生们也参加研究道德行为的课程。CBI项目主办了一个年度研讨会，在研讨会上，现有的学员展示了他们的研究成果，新学员被介绍到该项目中。作为培训计划的一部分，还邀请了知名的外部演讲者。一位以前的CBI学生被邀请帮助现在的CBI学生发展他们的职业生涯。在这个为期两年的课程接近尾声时，学生们申请参加一个外部地点的暑期工作坊课程，在这个课程中，课堂教学和实验室教学在一个紧张的科学环境中结合在一起。CBI计划还支持CBI的学生每年参加一次科学会议。

DESCRIPTION (provided by applicant): Multidisciplinary research at the Chemistry: Biology interface has expanded so rapidly in the past few decades that such cross-training is now crucial for the development of the next generation of chemists and biologists. The objectives of the proposed training program at Texas A&M University are to train predoctotal graduate students in the Chemistry, Biochemistry and Biophysics, and Biology departments in research at the Chemistry: Biology Interface (CBI). Since its inception in 1994, this NIH-sponsored program has played a major role in the successful training of our graduate students in the molecular life sciences. The program currently involves 27 faculty members, with highly diverse research interests including : a) mechanistic enzymology (Raushel), b) macromolecular interactions (Hu, Reinhart, Schultz); c) synthesis (Burgess,Connell, Darensbourg, Romo, Yang); d) bioanalysis (Cremer, Russell, Vigh); e) metabolism (Begley, Lindahl,Watanabe); f) structure/function relationships (Barondeau, Hilty, Sacchettini); g) computational reaction mechanisms (Gao, Singleton); h) chronobiology (Golden and Bell-Pederson); i) behavioral biology (Garcia)and j) chemical biology (Pellois, Liu, Ryan, Young). Such diversity is a major strength of our CBI program, as it makes it attractive to a wider range of students and affords for greater cross-training at the Chemistry: Biology interface. Students in the CBI program choose one of these trainers as their primary research advisor, and enroll in a core group of required courses in which training in quantitative biology is stressed. CBI students enroll in a weekly journal club, in which research topics from this area are discussed, emphasizing the connection to human health, physiology and disease. Students also enroll in class on the Ethical Conduct of Research. The CBI program sponsors an annual symposium in which existing trainees present their research results and new trainees are introduced into the program. Well known external speakers are also invited as part of the training program. A former CBI student is invited to help current CBI students develop their careers. Towards the end of this 2-year program, students apply to attend a summer workshop course at an external location in which classroom and laboratory instruction are combined in an intense scientific setting. The CBI program also supports CBI students to attend a scientific conference annually.