STUDIES OF VISUAL PROCESSING & SMOOTH EYE MOVEMENTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们的研究旨在确定与正常和病理性平滑追踪、眼球运动和凝视保持相关的视觉处理的神经基础。在对正常猴子的研究中，我们证明了意志性眼跳调节了MSTD反应的视觉敏感度，包括显著缩短视觉潜伏期。我们还证明了MSTd中的神经元在平稳追踪和眼球跟随过程中携带与眼速相关的信号。这项工作具有重要的意义，表明MST是一个多模式的皮质区域，在监测和产生眼动方面发挥着作用。 我们对斜视猴子的免费研究表明，与正常猴子不同，MSTd神经元具有强烈的视觉偏好。因此，MST是皮质追踪系统中的一个重要节点，对灵长类动物早期视觉体验的质量和感觉-运动功能的发展非常敏感。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our studies are directed at defining the neural substrate for visual processing related to normal and pathological smooth pursuit eye movements and gaze-holding. In studies of normal monkeys we have demonstrated that volitional saccades modulate the visual sensitivity of responses in MSTd, including significantly shortening visual latency. We also demonstrated that neurons in MSTd carry a signal related to eye velocity during smooth pursuit and ocular following. This work is significant in showing that MST, which is a multimodal cortical area, plays a role in both monitoring and generating eye movements. Our complimentary studies in strabismic monkeys show that MSTd neurons have strong ocular preferences unlike that found in normal monkeys. Therefore, MST is an important node in the cortical pursuit system and is sensitive to the quality of early visual experience and development of sensory-motor function in primates.