GENERALIZED INSTRUMENT CONTROL AND AUTOMATION SOFTWARE DEVELOPMENT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 通用仪表控制和自动化软件开发 该子项目的总体目标是通过开发、改进和应用软件技术来集成仪器、计算和信息技术，提高我们从设施中的光学和电子显微镜（LM/EM）以及我们的相关资源中获取数据的能力。具体地，我们的目标是通过利用和扩展我们的可扩展的通用远程显微镜系统来增加数据采集和分析吞吐量，并增加记录的关于数据收集和仪器配置的信息的质量和范围（Molina等人，2005年）。该系统旨在集成、组织和统一成像仪器和附件（探测器、载物台等）的控制。并将其使用安全地与先进的网络基础设施相结合，包括数据管理和存储、高性能计算和信息学资源。 这一软件结构正在得到扩展，以便将具有独特价值的仪器纳入该中心的中尺度成像目标，特别是即将投入使用的FEI Titan STEM/TEM。 沿着将开发数据驱动和计算增强的自动化计划，同时提供支助服务，以组织和协调每台仪器提供的日益庞大的数据量。统一的接口也被开发，以简化如何手动，自动化，基本和先进的功能，介绍给生物医学研究人员。实现这些目标所需的步骤利用、扩展和完善GTS，以集成关键的多模态成像仪器（本地和远程），从而实现高通量中尺度成像的高级控制和自动化;通过完善GTS的功能，提高我们的数据处理性能并完善会话状态报告。最后，我们将开发一个软件原型环境，以简化、促进和简化基于仪器的新型应用程序的开发，包括自动化和数据驱动的反馈方案。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. GENERALIZED INSTRUMENT CONTROL AND AUTOMATION SOFTWARE DEVELOPMENT This subproject's general objective is to enhance our ability to acquire data from light and electron microscopes (LM/EM) at the facility as well as at our allied resources, by developing, refining, and applying software technologies to integrate instrumentation, computing, and informatics technologies. Specifically, we aim to increase data acquisition and analysis throughput and increase the quality and extent of information logged about data collection and instrument configuration by leveraging on and expanding our scalable generalized telemicroscopy system (Molina et al., 2005). This system is designed to integrate, organize, and unify the control of imaging instruments and accessories (detectors, stages, etc.) and securely couple their use to advanced cyberinfrastructure, including resources for data management and storage, high-performance computing, and informatics. This software architecture is being extended to integrate instruments of unique value to the mesoscale imaging aims of the Center, in particular the incoming FEI Titan STEM/TEM. Data-driven and computationally enhanced automation schemes will be developed along with supporting services to organize and coordinate the increasingly large data volumes delivered from each instrument. Unifying interfaces are also be developed to simplify how manual, automated, basic, and advanced features are presented to the biomedical researcher. The steps necessary for achievement of these goals leverage, extend, and refine the GTS to integrate key multimodal imaging instruments (local and remote) to enable advanced control and automation for high-throughput mesoscale imaging; increasing our data handling performance and refining session state reporting through refinements to the capabilities of the GTS. Lastly, we shall develop a software prototyping environment to streamline, promote, and simplify the development of novel instrument-based applications, including automation and data-driven feedback schemes.