Lipid Biology and Lipotoxicity

描述（由申请人提供）：本提案要求支持由Scott a . Summers和Rudolf Zechner组织的题为脂质生物学和脂质毒性的Keystone专题会议，该会议将于2011年5月15日至20日在爱尔兰Kerry Co. Killarney举行。脂肪在不适合储存脂肪的组织中积累会对器官功能产生有害影响，导致细胞损伤，从而成为糖尿病、心脏病和高血压的基础。说明这种关系的事实是，许多有效的治疗方法通过限制外周组织中脂肪的不适当沉积来改善代谢性疾病症状（例如，噻唑烷二酮类药物、二甲双胍或他汀类药物）。基因组学和脂质组学的最新进展为研究人员提供了一个机会，使他们能够在理解和治疗由脂肪过量产生和/或利用不足引起的致病性疾病方面取得实质性的飞跃。本次会议回顾了这些领域，特别强调以下方面：(a)异位脂质沉积与代谢性疾病之间的关系；(b)脂质过剩改变组织功能的机制；(c)控制脂质储存和代谢的调节过程；(d)脂质分析领域的技术进步（即脂质组学）。关于心血管疾病的专题将提供对心脏致病性事件的病因学的见解，许多会议将推进关于异常脂肪代谢与心脏、肺和血液疾病之间基本关系的知识。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Lipid Biology and Lipotoxicity, organized by Scott A. Summers and Rudolf Zechner, which will be held in Killarney, Co. Kerry, Ireland from May 15 - 20, 2011. The accumulation of fat in tissues not suited for lipid storage has deleterious consequences on organ function, leading to cellular damage that underlies diabetes, heart disease, and hypertension. Illustrating the relationship is the fact that numerous effective therapeutics ameliorate metabolic disease symptoms by limiting the inappropriate deposition of fat in peripheral tissues (e.g., thiazolidinediones, metformin, or statins). Recent advances in genomics and lipidomics offer researchers an opportunity to make a substantial leap in the understanding and treatment of pathogenic conditions resulting from the excessive production and/or underutilization of fat. This meeting reviews these areas, placing specific emphasis on the following: (a) relationships between ectopic lipid deposition and metabolic disease; (b) mechanisms through which lipid excess alter tissue function; (c) regulatory processes that control lipid storage and metabolism; and (d) technological advances in the area of lipid analysis (i.e., lipidomics). Dedicated topics on cardiovascular disease will provide insight into the etiology of pathogenic events in the heart and numerous the sessions will advance knowledge on the fundamental relationships between abnormal fat metabolism and heart, lung, and blood disorders.