Mechanisms of Cardiac Growth, Death and Regeneration

描述（由申请人提供）：本提案要求支持由Richard N. Kitsis、Ivor J. Benjamin和Charles E. Murry组织的题为“心脏生长、死亡和再生机制”的Keystone专题会议，该会议将于2011年2月22日至27日在科罗拉多州的Keystone举行。心血管疾病是世界上导致死亡的主要原因。尽管我们对心脏生物学和病理生物学的理解取得了进展，但仍然存在重大的概念和实践差距。本次会议-结合同期召开的分子心脏病学：疾病机制和实验治疗学会议-将通过关注调节心脏结构、功能和修复的基本机制以及它们与人类疾病的关系来解决这些空白。这些以心血管为中心的配对会议将不同领域集中在健康和疾病中的心脏。虽然主要以基础科学为基础，但每次会议都独特地结合了从实验室到床边的新疗法会议，目的是扩大会议对来自学术界、制药、生物技术和临床企业的研究人员的吸引力。这两个会议都涉及肥厚、心力衰竭和疾病。心脏生长、死亡和再生机制会议的重点包括干细胞和干细胞/组织工程，因此这次会议在心脏干细胞生物学会议中占有独特的地位。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Mechanisms of Cardiac Growth, Death and Regeneration, organized by Richard N. Kitsis, Ivor J. Benjamin and Charles E. Murry, which will be held in Keystone, Colorado from February 22 - 27, 2011. Cardiovascular disease is the major cause of death in the world. Although advances have been made in our understanding of cardiac biology and pathobiology, significant conceptual and practical gaps remain. This meeting - in combination with a concurrent meeting on Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics - will address these gaps by focusing on fundamental mechanisms that regulate cardiac structure, function, and repair and how they relate to human disease. These paired cardiovascular-centric meetings bring diverse areas under an umbrella focused on the heart in health and disease. While primarily basic science-based, each meeting uniquely incorporates bench-to-bedside novel therapeutics sessions with the goal of broadening the attraction of this meeting to investigators from academia, pharma, biotechnology, and in the clinical enterprise. Both meetings deal with hypertrophy and heart failure, and disease. The focus of the Mechanisms of Cardiac Growth, Death and Regeneration meeting includes stem cells and stem cell/tissue engineering, and therefore this meeting occupies a unique position with respect to cardiac stem cell biology meetings. PUBLIC HEALTH RELEVANCE: Myocardial infarction and heart failure are the two major cardiac syndromes that are the most common causes of mortality in the United States and the world. The Keystone Symposia meeting on Mechanisms of Cardiac Growth, Death and Regeneration addresses the molecular underpinnings of the most fundamental decisions made by cardiac cells: a) to differentiate from their progenitors; b) to grow; or c) to survive or to die. This meeting, held in tandem with a meeting on Molecular Cardiology, will involve scientific questions relevant both to the cardiovascular system and stem cell biology as a whole.