Bio-behavioral Consequences of Appearance and Performance Enhancing Drug Use

拟议的K23以病人为本的职业发展奖旨在为私家侦探提供 进行必要的培训，以研究外貌和外貌的生物行为后果的个体变异性 提高成绩药物(APED)的使用。应聘者：PI是助理教授，临床执业证书 目前在西奈山医学院(MSSM‘s)工作的心理医生 精神障碍项目。他计划使用K23成为R01资助的研究员，与 基础科学家和翻译科学家关于使用APED带来的临床、伦理和科学挑战。在……里面 为了实现这些职业目标，他将使用K23来获得必要的知识、技能和能力 儿童内分泌/神经内分泌功能与攻击性/冲动性关系的研究 被模仿的用户。他的具体培训目标是：(A)学习理论、方法和临床 研究病理性和非病理性使用类人猿的区别的方法，(B) 通过翻译研究开发可用的理论和方法的实用知识，以 研究荷尔蒙-行为关系；(C)获得荷尔蒙相关理论和方法方面的专业知识 对精神疾病的失调，(D)更好地了解医疗、法律和伦理 与研究药物滥用有关的问题，以及(E)获得纵向数据建模和 生物数据的统计分析。环境：PI提出的培训计划和职业目标是 与MSSM精神病学部的使命声明一致，将翻译和 临床研究，特别是在神经内分泌学领域。希尔德布兰特医生为他提供了 丰富的专业知识和可用的资源，包括实验室，有助于研究这两种内分泌 和神经内分泌功能。研究：使用类人猿最可靠的精神后果是 冲动攻击性增加，尽管观察到了一系列精神障碍。这个 监督研究项目将是对荷尔蒙和精神疾病程度的纵向研究 60只成年雄性类人猿使用者在不同时间(周期内和周期外)的调节失调(攻击性和冲动) 与20岁的对照组相比，锻炼和受教育程度匹配。分段潜在增长曲线建模将 被用来调查周期内和周期外的变化，以下变化的预测因素将是 探索：类人猿的特征(数量、持续时间和模式)、年龄、精神病史、个性和 使用类人猿的历史)。相关性：这项拟议研究的结果将有助于确定内分泌 对类人猿使用和使用者特征造成精神后果的功能障碍 对这些精神后果的预测。这项研究的意义在于为预防提供信息， 与这一日益增长的公共卫生问题相关的干预和基于政策的决定。

The proposed K23 Patient-Oriented Career Development Award is designed to provide the PI with the training necessary to study the individual variability in bio-behavioral consequences of appearance and performance enhancing drug (APED) use. Candidate: The PI is an Assistant Professor and licensed clinical Dsychologist currently working at the Mount Sinai School of Medicine's (MSSM's) Eating and Weight Disorders Program. He plans to use the K23 to become an R01 funded researcher that works closely with basic and translational scientists on the clinical, ethical, and scientific challenges presented by APED use. In order to obtain these career goals, he will use the K23 to acquire knowledge, skills, and abilities necessary to the study the relationship between endocrine/neuroendocrine function and agression/impulsivity among APED users. His specific training objectives are to (a) learn the theoretical, methodological, and clinical approaches to studying the distinction between pathological and non-pathological forms of APED use, (b) develop a working knowledge of the theory and methodology available through translational research to study hormone-behavior relationships, (c) acquire expertise in the theory and methodology linking hormone dysregulation to psychiatric illness, (d) acquire greater understanding of the medical, legal, and ethical issues associated with studying substance abuse, and (e) obtain expertise in longitudinal data modeling and statistical analysis of biological data. Environment: The Pi's proposed training plan and career goals are consistent with the MSSM Department of Psychiatry's mission statement to integrate translational and clinical research, particularly in the area of neuroendocrinology. Dr. Hildebrandt has available to him a wealth of expertise and resources available including the lab facilitates necessary to study both endocrine and neuroendocrine functioning. Research: The most reliable psychiatric consequence to APED use is increased impulsive aggression although a range of psychiatric disturbances have been observed. The supervised research project will be a longitudinal study of the degree of both hormone and psychiatric dysregulation (aggression and impulsivity) in 60 adult male APED users across time (on-cycle and off-cycle) compared to 20 age, exercise, and education matched controls. Piecewise latent growth curve modeling will be used to investigate changes on-cycle and off-cycle changes and the following predictors of change will be explored: APED characteristics (amount, duration, and pattern), Age, Psychiatric History, Personality, & History of APED use). Relevance: Findings from the proposed study will help identify both the endocrine dysfunction responsible for the psychiatric consequences to APED use and the user characteristics predictive of these psychiatric consequences. Implications of this research are to inform prevention, intervention, and policy based decisions related to this growing public health concern.