UNC-CH NADIA Administrative Core

描述(由申请人提供)：本申请的目的是为“青少年成年期饮酒的神经生物学”(NAIDA)倡议发展一个联合体。Nadia将在一个多学科研究项目中协调不同的基础神经科学家小组，以明确定义青少年酒精暴露对成年人的持续影响，并开始探索神经生物学机制。该联盟的主要假设是，人类未成年饮酒的模式将影响大脑成熟，导致与行为变化相关的成人大脑功能和结构的持续变化。Nadia将使用青春期间歇性乙醇(AIE)大鼠模型，模拟青春期未成年饮酒的间歇性。多个研究组成部分将整合分子、细胞、生理、内分泌、遗传、神经解剖学和行为研究，利用尖端和新的方法来调查人类未成年人饮酒的潜在长期后果。大量的证据表明，在青春期，认知、情感和奖励驱动的行为模式是独特的可塑性，并对环境影响做出反应。作为动机、情感和决策基础的大脑回路的成熟，预计会对酒精干扰敏感，导致成人精神病理增加。该联盟将整合共享共同假设和重叠方案的调查人员。每一项都将有助于更好地理解青少年酒精暴露对大脑生理、结构、化学、成熟以及情感、动机、社会功能、决策认知评估、冲动、昼夜节律和饮酒行为的行为诱导的影响。内容涵盖了额叶皮质、纹状体、海马体、杏仁核和下丘脑核之间神经回路的广泛相互关联的研究，以及下丘脑-肾上腺相互作用的荷尔蒙成熟的性别，提供了复杂行为成熟基础的神经网络发展的广泛的全球调查。科学核心将提供脑MRI-DTI(脑体积-结构)、脑区域组织学-免疫组织化学的组件，并为未来的脑网络分析建立一个数据存储库。了解未成年人饮酒对成人神经生物学的影响对于指导公共卫生倡议非常重要。

DESCRIPTION (provided by applicant): The purpose of this application is to develop a Consortium for the initiative "Neurobiology of Adolescent Drinking in Adulthood" (NADIA). The NADIA will coordinate a diverse group of basic neuroscientists in a multidisciplinary research project to clearly define the persistent effects of adolescent alcohol exposure on adults, and to begin to explore the neurobiological mechanisms. The overarching hypothesis of this consortium is that models of human underage drinking will impact brain maturation resulting in persistent changes in adult brain function and structure that relate to changes in behavior. This NADIA will use adolescent intermittent ethanol (AIE) rat models that mimic episodic human adolescent underage drinking. Multiple research components will integrate molecular, cellular, physiological, endocrine, genetic neuroanatomical and behavioral studies utilizing cutting edge and novel approaches to investigate potential long term consequences of human underage drinking. An abundance of evidence suggests that during adolescence, cognition, affect, and reward driven behavioral repertoires are uniquely plastic and responsive to environmental influences. Maturation of brain circuitry that underlies motivation, affect and decision making are expected to be sensitive to ethanol disruption, resulting in increased adult psychopathology. This consortium will integrate investigators that share common hypotheses and overlapping protocols. Each will contribute to an improved understanding of the consequences of adolescent alcohol exposure on brain physiology, structure, chemistry, maturation and behavioral induces of affect, motivation, social functioning, decision-making cognitive assessments, impulsivity, circadian rhythms, and alcohol drinking behaviors using AIE. Components cover broad inter-related investigations of the neurocircuitry between frontal-cortical, striatal, hippocampal, extended amygdala and hypothalamic nuclei as well as hormonal maturation of hypothalamic-adrenal interactions across gender, providing a broad global investigation of the development of neural networks that underlie maturation of complex behaviors. The scientific core will provide components with brain MRI-DTI (brain volume - structure), brain regional histology-immunohistochemistry and establish a data repository for future brain network analysis. Understanding the impact of underage drinking on adult neurobiology is important to guide public health initiatives.