Cancer and Metabolism

描述（由申请人提供）：本提案要求支持由Reuben J. Shaw和David M. Sabatini组织的题为“癌症与代谢”的Keystone专题会议，该会议将于2012年2月12日至17日在加拿大阿尔伯塔省班夫举行。尽管在20世纪20年代，Otto Warburg首次将葡萄糖代谢的改变作为肿瘤细胞的一个特征，但直到过去十年，这一观察的分子基础才开始得到充分的认识。这个领域在过去的五年中随着对真正的肿瘤抑制基因和致癌基因与代谢控制的广泛相互作用的识别而迅速发展。肿瘤细胞生物合成需求的增加要求细胞代谢的重编程，这也增加了能量需求，使肿瘤细胞更容易受到针对其代谢的干预。Keystone癌症和代谢专题讨论会的目标是将癌症和代谢控制领域的领导者与研究连接和控制它们的信号通路的人聚集在一起。将讨论最新的发现，以及如何利用这些知识来设计未来的癌症治疗方法。同时举行的“缺氧信号的进展：从实验室到床边”会议将大大增加跨学科互动的机会，该会议将与本次会议分享主题演讲和全体会议。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Cancer and Metabolism, organized by Reuben J. Shaw and David M. Sabatini, which will be held in Banff, Alberta, Canada from February 12 - 17, 2012. Although altered glucose metabolism was first noted as a characteristic of tumor cells by Otto Warburg in the 1920s, the molecular underpinning for this observation did not begin to be appreciated fully until the past decade. And this area has exploded over the last five years with the identification of extensive interactions of genuine tumor suppressor genes and oncogenes with metabolic control. The increased biosynthetic needs of tumor cells demands a reprogramming of cellular metabolism, which also creates increased energy demands and makes tumor cells more vulnerable to interventions targeting their metabolism. The goal of the Keystone Symposia meeting on Cancer and Metabolism is to bring together leaders in the fields of cancer and metabolic control with those studying the signaling pathways linking and governing each. The latest discoveries will be discussed as well as how this knowledge can be exploited to design future cancer therapeutics. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Advances in Hypoxic Signaling: From Bench to Bedside, which will share a keynote address and a plenary session with this meeting. PUBLIC HEALTH RELEVANCE: Most tumors undergo altered metabolism - a feature that can be used to non-invasively monitor tumor growth, progression, and therapeutic response. As tumor cells experience increased energy demands they become more vulnerable to interventions targeting their metabolism; major efforts are underway to develop therapeutics to target this cancer cell-specific sensitivity. The Keystone Symposia meeting on Cancer and Metabolism will bring together leaders in the fields of cancer and metabolic control with those studying the signaling pathways linking and governing each. The latest discoveries will be discussed as well as how this knowledge can be exploited to design future cancer therapeutics.