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Gene Expression Profiling and Clinical Characterization of Phototoxicity

Gene Expression Profiling and Clinical Characterization of Phototoxicity
光毒性的基因表达谱和临床特征
批准号：
8349232
负责人：
Heidi Kong
金额：
$3.38万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8349232
关键词：
BiopsyClinicalCutaneousCytochrome P450DataDiureticsDoxycyclineGene ExpressionGene Expression ProfilingGenotypeGoalsImmunohistochemistryLightMicroarray AnalysisNon-Steroidal Anti-Inflammatory AgentsPathway interactionsPharmaceutical PreparationsPhototoxicityProtocols documentationReactionRecommendationRoleSignal TransductionSkinSunscreening AgentsTestingUltraviolet RaysVisible RadiationVoriconazoleantimicrobialhealthy volunteertranslational approachultraviolet

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中文摘要
翻译
在2011财年，我们继续验证我们的微阵列数据，这些数据来自皮肤光毒性的皮肤活检。初步分析表明，与对照皮肤相比，单独使用多西环素(没有紫外线或光线照射)的皮肤中存在基因表达信号。我们在2010年修改了我们的方案，允许我们用多西环素重新治疗健康志愿者，以获得更多的活检。2011财年，我们又治疗了4名健康志愿者。我们一直在对这些额外的活检组织进行免疫组织化学检查，以验证微阵列数据。
英文摘要
In fiscal year 2011, we continued to validate our microarray data obtained from skin biopsies of skin phototoxicity. The initial analysis demonstrated that there were gene expression signals in skin treated with doxycycline alone (without ultraviolet or light exposure) compared to control skin. We amended our protocol in 2010 to allow us to re-treat healthy volunteers with doxycycline to obtain additional biopsies. We treated 4 additional healthy volunteers in fiscal year 2011. We have been performing immunohistochemistry on these additional biopsies to validate the microarray data.
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