Toxicity Of Lead In Children--Clinical Trial

我们进行了琥珀酸类药物治疗中度铅中毒儿童的临床试验。我们没有发现琥珀酸治疗对认知或行为的影响，这是先前报道的。最近，我们已经与疾控中心安排对该项目中采集的血液样本进行甲基汞、无机汞和镉的分析，这允许在不招募任何新的受试者或收集任何样本的情况下，对琥珀酸络合这些化合物进行随机试验。蔗糖分子似乎不是汞或镉的有效螯合剂。在2岁时测量的汞和镉都与认知或行为测试分数无关，镉与血压也没有关联。7岁时的汞与儿童智商的小幅增长有关，可能是因为汞的来源是食用鱼类，而鱼类含有用于大脑发育的多不饱和脂肪酸。我们正在调查是否可以分析样品中的脂肪酸，并解开这些影响。

We did a clinical trial of succimer to treat moderately lead poisoned children. We found no effect of succimer treatment on cognition or behavior, reported previously. Recently, we have arranged with CDC to analyze blood samples collected in this project for methyl mercury, inorganic mercury, and cadmium, which allowed a randomized trial of succimer for chelation of these compounds without enrolling any new subjects or collecting any specimens. Succimer does not appear to be an efficacious chelating agent for mercury or cadmium. Neither mercury nor cadmium, measured at age 2 years, is associated with cognitive or behavioral test scores, and cadmium is not associated with blood pressure. Mercury at 7 years is associated with a small increase in the child's IQ, probably because the source of the mercury is dietary fish, and fish contains polyunsaturated fatty acids that are used in brain development. We are investigating whether we can analyze the samples for fatty acids and disentangle these effects.