Regenerative Tissue Engineering and Transplantation

描述(由申请人提供)：本提案请求支持由Rocky S.Tuan、Farshid Guilak和Anthony Atala组织的题为再生组织工程和移植的Keystone研讨会，该会议将于2012年4月1日至6日在科罗拉多州布雷肯里奇举行。组织工程和再生医学是一个动态的、转化的研究领域，它融合了生命科学、工程学和临床医学，目的是恢复疾病、损伤或损伤的组织和器官的结构和功能。目前的努力集中在干细胞和祖细胞、生物活性因子和生物材料支架在移植过程中的应用，以影响再生治疗。在膀胱和气管重建方面取得了突破，在固体器官再生以及肌肉骨骼和神经修复方面也取得了非常有希望的方法。有效的细胞来源，组织衍生和合成生物材料支架的最佳组装和制造，以及干细胞治疗和免疫调节功能的靶向调控，是这一领域目前面临的一些挑战。在这次再生组织工程和移植的Keystone研讨会上，专家科学家、工程师和临床医生将综合该领域令人兴奋的技术和智力进步，以评估和扩大再生工程和移植的前景。关于整个器官再生机制的并行会议将大大增加跨学科互动的机会，该会议将与本次会议分享开幕式和闭幕式主旨演讲以及两次全体会议。更具体地说，这两个会议的配对代表着一个非常不寻常的机会，可以在更多应用驱动的组织工程和再生医学领域与正在探索的整个器官再生领域的非常基础的研究之间进行交叉。 公共卫生相关性：由于疾病、损伤和创伤造成的组织和器官的结构和功能丧失是医学上的一个重大挑战。先进的再生和移植技术的发展对这些受影响的人来说是至关重要的。再生组织工程和移植的Keystone研讨会会议将直接解决这一领域的挑战。关于整个器官再生机制的并行会议将大大增加跨学科互动的机会，该会议将与本次会议分享开幕式和闭幕式主旨演讲以及两次全体会议。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Regenerative Tissue Engineering and Transplantation, organized by Rocky S. Tuan, Farshid Guilak and Anthony Atala, which will be held in Breckenridge, Colorado from April 1 - 6, 2012. Tissue engineering and regenerative medicine is a dynamic, translational research field that amalgamates life sciences, engineering, and clinical medicine for the purpose of restoring structure and function to diseased, damaged or injured tissues and organs. Current efforts focus on the application of stem and progenitor cells, bioactive factors and biomaterial scaffolds in transplantation procedures to affect regenerative therapies. Breakthroughs in bladder and tracheal reconstruction and highly promising approaches for solid organ regeneration as well as musculoskeletal and nerve repair have been achieved. Effective cell sourcing, optimal assembly and fabrication of tissue-derived and synthetic biomaterial scaffolds, and targeted regulation of therapeutic and immunomodulatory functions of stem cells represent some of the current challenges in this field. In this Keystone Symposia meeting on Regenerative Tissue Engineering and Transplantation, exciting technological and intellectual advances in the field will be synthesized by expert scientists, engineers, and clinicians to assess and expand the landscape in regenerative engineering and transplantation. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Mechanisms of Whole Organ Regeneration, which will share an opening and closing keynote address as well as two plenary sessions with this meeting. More specifically, the pairing of these 2 meetings represents a highly unusual opportunity for crosstalk between the more applications-driven field of tissue engineering and regenerative medicine, and the very basic research being explored in the field of whole organ regeneration. PUBLIC HEALTH RELEVANCE: Structural and functional loss of tissues and organs through disease, injury, and trauma is a significant challenge in medicine. Development of advanced regenerative and transplantation technologies is of essential benefit to these affected individuals. The Keystone Symposia meeting on Regenerative Tissue Engineering and Transplantation will directly address challenges in this field. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Mechanisms of Whole Organ Regeneration, which will share an opening and closing keynote address as well as two plenary sessions with this meeting.