POSTDOCTORAL TRAINING

描述(由申请者提供)：该计划培训内科科学家和博士后科学家在创伤和危重疾病后发生的病理生理过程方面的知识。在过去的4年里，我们成功地招聘到了我们的职位，并解决了我们在上一次竞争更新中提出的关于我们项目多样性的关键问题。我们特别注意确定和招募人数不足的强有力的少数族裔候选人。我们之前的竞争更新也集中在“关键举措”上，这是由国家卫生研究院的领导人定义的，并被称为“NIH路线图”。这直接关系到这次培训的结构和方向。简而言之，主要的倡议或主题是：(1)新的发现途径，(2)未来的研究团队和(3)临床研究企业的重组。我们建议继续对受训人员进行现有分子生物学技术的教育，并将扩大他们的培训范围，以包括尖端研究和分析(即生物医学计算)技术。通过与基础科学家的合作以及与华盛顿大学现有研究教育项目的整合，我们将让学员接触到基础广泛的研究团队和项目。受训人员的教育和经验将继续包括转化性研究的概念，据此，基本观察将被评估为对危重患者的潜在诊断和治疗益处。总而言之，我们的目标是培养一批感兴趣的科学家，使他们成为独立的研究人员和教育工作者，从事学术事业。通过多学科和协作的努力，学员学习如何识别重要的研究问题，如何设计、进行和分析将解决这些问题的实验，以及如何将他们的发现转化为临床相关的干预措施。相关性：创伤仍然是一个重要的公共卫生问题。在所有年龄段的人中，伤害是造成高比例死亡的原因，伤害受害者的医疗保健费用很高。我们的培训计划成功地在损伤和炎症的应用生物学方面对外科医生、内科医生和博士后学生进行了培训。我们项目的毕业生表现出了对了解损伤生物学和照顾危重伤害受害者的承诺。

DESCRIPTION (provided by applicant): The program trains physician-scientists and post-doctoral PhD scientists in aspects of the pathophysiological processes that occur after traumatic injury and critical illness. Over the past 4 years we have successfully recruited to fill our positions and have addressed a key concern that was raised in our previous competitive renewal regarding diversity in our program. We have paid particular attention to identifying and recruiting strong under-represented minority candidates. Our previous competitive renewal also focused upon the "key initiatives", defined by the leaders at the National Institutes of Health and termed the "NIH Roadmap". This had direct bearing on the structure and direction of this training program. Briefly, the key initiatives or themes are: (1) New Pathways to Discovery, (2) Research Teams of the Future and (3) Reengineering the Clinical Research Enterprise. We propose to continue to educate trainees in established molecular biology techniques and will expand their training to include cutting edge research and analysis (i.e. biomedical computing) techniques. Through collaborations with basic scientists and integration with the available research education programs at the University of Washington, we will expose trainees to broad-based research teams and programs. Trainee education and experience will continue to include concepts of translational research, whereby basic observations will be evaluated as potential diagnostic and therapeutic benefit for critically ill patients. In summary, we aim to prepare a diverse group of interested scientists for academic careers as independent investigators and educators. Through a multidisciplinary and collaborative effort, trainees learn how to identify important research questions, how to design, conduct and analyze experiments that will address these questions and how to translate their findings into clinically relevant interventions. RELEVANCE: Trauma remains an important public health problem. Injuries are responsible for a high proportion of deaths in people of all ages and medical care for injury victims is costly. Our training program has successfully educated surgeons, physicians and post-doctoral students in aspects of the applied biology of injury and inflammation. Graduates from our program have demonstrated a commitment to understanding the biology of injury and to the care of critically ill injury victims.