Noncoding RNAs in Development and Cancer

描述（由申请人提供）：由Joshua T. Mendell, Phillip a . Sharp， Judy Lieberman和Howard Y. Chang组织的题为“非编码rna在发展和癌症中的作用”的Keystone专题会议将于2013年1月20日至25日在加拿大不列颠哥伦比亚省温哥华举行。癌症生物学中一个反复出现的原则是在肿瘤细胞发育过程中促进异常行为的途径的共同选择。这一原则显然适用于非编码rna在癌症中的作用。修饰肿瘤表型的非编码rna的例子包括microRNA (miRNA) let-7，它是秀丽隐杆线虫发育时间的关键调节因子，以及miR-17-92簇，它在哺乳动物发育过程中发挥重要的调节功能。然而，我们目前对不同种类的非编码rna在生理和病理生理状态下的功能只有初步的了解。本次会议将汇集专注于非编码rna在发育和癌症中的作用的专家，其广泛目标是：1)阐明由mirna和长链非编码rna控制的发育和癌症途径之间的新联系；2)揭示发育和癌症途径影响非编码RNA加工和活性的新机制；3)揭示mirna和长链非编码rna在这些通路中发挥作用的分子机制；4)强调我们对非编码rna调控途径的理解如何应用于癌症和其他疾病的新治疗策略的开发。为了实现这些目标，本次会议将汇集来自不同领域的专家，从有机体水平的发育和癌症生物学到RNA功能的生化和分子研究，分享他们最新的数据和想法。预计与会者提出的不同观点、方法和结果将促进新的调查和合作路线，这将对剖析非编码rna在健康和疾病中的无数功能至关重要。

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Noncoding RNAs in Development and Cancer, organized by Joshua T. Mendell, Phillip A. Sharp, Judy Lieberman and Howard Y. Chang, which will be held in Vancouver, British Columbia, Canada from January 20 - 25, 2013. A recurrent principle in cancer biology is the co-option of pathways that function during development to promote aberrant tumor cell behavior. This principle clearly applies to the roles of noncoding RNAs in cancer. Examples of noncoding RNAs that modify tumor phenotypes include the microRNA (miRNA) let-7, a key regulator of developmental timing in C. elegans, and the miR-17-92 cluster, which conducts essential regulatory functions during mammalian development. However, we currently have only a rudimentary understanding of how diverse classes of noncoding RNAs function in physiologic and pathophysiologic states. This meeting will bring together experts focused on the roles of noncoding RNAs in development and cancer with the broad goals of 1) illuminating new connections between developmental and cancer pathways controlled by miRNAs and long noncoding RNAs; 2) uncovering novel mechanisms by which developmental and cancer pathways influence noncoding RNA processing and activity; 3) revealing the molecular mechanisms through which miRNAs and long noncoding RNAs function in these pathways; and 4) highlighting how our understanding of noncoding RNA-regulated pathways can be applied in the development of novel therapeutic strategies for cancer and perhaps other diseases. To accomplish these goals, this meeting will bring together experts from disparate fields ranging from organismal- level developmental and cancer biology to biochemical and molecular studies of RNA function to share their newest data and ideas. It is anticipated that the diverse views, approaches, and results presented by participants will foster new lines of investigation and collaborations which will be critical to dissect the myriad functions of noncoding RNAs in health and disease.