A structural and molecular investigation into the basic mechanism of T cell receptor complex function

细胞命运由膜结合受体及其同源配体之间的相互作用决定。这种受体介导的识别事件如何导致细胞内信号传递的基本机制在大多数生物系统中知之甚少，包括细胞免疫识别轴。这个项目将通过研究以T细胞受体复合体为中心的相互作用来探索细胞免疫的中心事件。这个项目将探索支持这些关键受体识别事件的分子机制，并将这些观察到的结果与T细胞激活联系起来。该提案将对主要组织相容性复合体限制、T细胞发育以及抗原识别如何导致T细胞信号转导提供基本的见解。

Cellular fate is determined by interactions between membrane-bound receptors and their cognate ligands. The basic mechanism of how such receptor-mediated recognition events cause intracellular signalling is poorly understood in most biological systems, including the cellular immune recognition axis. This project will explore events central to cellular immunity by examining the interactions centred on T-cell receptor complexes. This project will explore the molecular mechanisms underpinning these key receptor-recognition events and relate these observations to T-cell activation. The proposal will shed fundamental insight into Major Histocompatibility Complex restriction, T-cell development and how antigen recognition leads to T-cell signal transduction.