Training in Bioenergetics, Oxidative Stress and Metabolic Syndrome

描述（申请人提供）：该项目旨在培养生物能量学，氧化应激和代谢综合征（BOSMS）研究的博士后和博士后科学家。它的目标是在基础研究和临床研究领域培养有才华的年轻人，教他们设计和实施成功的研究项目，并在科学研究的伦理和方法方面提供坚实的背景。我们奖学金的目的是增加对代谢综合征，生物能量学和氧化应激在南卡罗来纳医科大学（MUSC）内的研究重点，并培养个人成为代谢综合征和相关疾病领域的独立研究者。受训者将从广泛的候选人中选出。将特别努力查明少数族裔申请人。BOSMS计划将分别为与一大群有才华的教师导师一起工作的博士生和博士后提供长达三年和两年的支持。研究项目集中在生物能量学和氧化应激领域，因为它们涉及代谢综合征的各个方面，包括胰岛素抵抗、糖尿病、肥胖、血脂异常、肝脂肪变性、炎症和随之而来的组织损伤。每周与受训者的会议使他们能够向研究界展示他们的材料。此外，受训人员必须在内部部门讨论会和利益小组会议上提出他们的研究，并向国家会议提交摘要。博士预科生将通过研究生院入学，并按照生物医学科学博士课程学习。在接受细胞、分子和有机体生物学的基础训练后，博士生预科生将参加生物能量学和氧化应激特别是与代谢综合征相关的研究生课程。所有学员将参加“负责任的研究行为”、“临床研究方法”和“生物医学研究的统计方法”等课程。学员还将有机会参加MUSC提供的各种研究主题的研究生课程，以提高他们的培训经验。指导委员会将协助项目主任招聘和选择学员，批准研究和教学计划，将学员分配给研究培训学院，并监督项目活动。内部和外部咨询委员会将对培训计划提供额外的评估，并向指导委员会和项目主任提供反馈。研究培训教师是由现有的NIH或其他校外资助的研究人员组成的，他们是经验丰富的导师。教师有不同的兴趣，允许多个候选人在培训计划中找到合适的导师。额外的临床医生-科学家导师将通过讨论研究的临床维度来指导受训者。大量的科研资源和临床资源为培养代谢综合征领域未来院士的年轻研究者提供了丰富的环境。

DESCRIPTION (provided by applicant): This is a program designed to train pre- and post-doctoral scientists in research on Bioenergetics, Oxidative Stress and Metabolic Syndrome(s) (BOSMS). Its goals are to nurture talented young individuals in the areas of basic research and clinical investigation, teach them the design and conduct of successful research projects, and provide a solid background in the ethics and methods of scientific research. The objective of our fellowships is to increase the focus of research on metabolic syndrome, bioenergetics and oxidative stress within the Medical University of South Carolina (MUSC) and to train individuals to become independent investigators in the area of metabolic syndrome and related diseases. Trainees will be selected from a broad group of candidates. Special efforts will be made to identify minority applicants. The BOSMS program will provide up to three and two years of support, respectively, for predoctoral and postdoctoral fellowsworking with a large group of talented faculty mentors. Research projects are concentrated in the areas of bioenergetics and oxidative stress as they relate to various aspects of the metabolic syndrome, including insulin resistance, diabetes, obesity, dyslipidemia, hepatic steatosis, inflammation and consequent tissue injury. Weekly conferences with the trainees allow them to present their material to the research community. Additionally, trainees are required to present their research at in-house departmental seminars and interest group meetings and to submit abstracts to national meetings. Predoctoral students will matriculate through the College of Graduate Studies and follow the course of study for the PhD in Biomedical Sciences. After receiving basic training in cell, molecular and organismal biology, predoctoral trainees will participate in graduate courses on bioenergetics and oxidative stress especially in relation to the metabolic syndrome. All trainees will attend courses on "Responsible Conduct of Research", "Methods in Clinical Research", and "Statistical Methods in Biomedical Research". Trainees will also have the opportunity to attend graduate level courses on a variety of research topics available at MUSC to enhance their training experience. The Steering Committee will assist the Program Director in recruitment and selection of trainees, approval of research and didactic plans, assignment of trainees to Research Training Faculty, and monitoring of program activities. Internal and External Advisory Committees will provide additional evaluation of the training program and feedback to the Steering Committee and Program Director. Research Training Faculty are established investigators with current NIH or other extramural funding and are experienced mentors. The faculty has diverse interests, allowing multiple candidates to find appropriate mentors within the training program. Additional Clinician- Scientist mentors will provide guidance to trainees through discussion of the clinical dimensions of the research. The large number of research resources MUSC and clinical resources offer a rich environment for the training of young investigators who will become future academicians in the area of metabolic syndrome.