Production of Pedigreed SPF Rhesus Macaques

描述（申请人提供）：该提案的目标是继续扩大具有遗传特征的印度血统恒河猴的生产，这些恒河猴对7种持续存在的病毒无特异性病原体（SPF），包括猿猴免疫缺陷病毒（SIV）、猿猴D型逆转录病毒（SRV）、猿猴T淋巴细胞病毒（STLV）、猕猴疱疹病毒1型（B病毒）、猿猴泡沫病毒（SFV）、恒河猴巨细胞病毒（RhCMV）和恒河猴鼻状病毒（RRV）。这一拟议的扩展将适合于生产SPF动物用于艾滋病相关研究，并建立一个长期自我维持的SPF繁殖群的印度起源的恒河猴与已知的血统和明确的MHC基因型。这个群体现在超过350只动物，通过自然分娩和SPF母亲的养育而自我维持。不再需要通过托儿所养育传统育种者所生婴儿来获得SPF育种者。

DESCRIPTION (provided by applicant): The goal of this proposal is to continue to expand the production of genetically characterized rhesus macaques of Indian-ancestry that are specific pathogen-free (SPF) for seven persistent viruses, including simian immunodeficiency virus (SIV), simian type D retrovirus (SRV), simian T-lymphotropic virus (STLV), Cercopithecine herpesvirus 1 (B virus), simian foamy virus (SFV), rhesus cytomegalovirus (RhCMV) and rhesus rhadinovirus (RRV). This proposed expansion will be geared to the production of SPF animals for use in AIDS-related research, and to establishing a long-term self-sustaining SPF breeding colony of Indian- origin rhesus macaques with known pedigree and well-defined MHC genotypes. This colony now exceeds 350 animals and is self-sustaining through natural birth and rearing by SPF mothers. Derivation of SPF breeders through nursery-rearing of infants born to conventional breeders is no longer required.