Center for Molecular, Cellular, and Translational Immunology

基于最初10年奖励的成功，此次COBRE更新申请的最终目标是 完成在达特茅斯建立一个国家认可的分子，细胞， 转化免疫学研究，并将这个COBRE免疫学研究中心 （COBRE-CIR）到一个基于基础设施的，独立的（来自COBRE资金），可持续发展的中心， 年随着长期免疫学计划的建立，该计划现已得到实质性进展 在COBRE的支持下，该提案利用了高度互动的协作核心， 达特茅斯医学院（DMS）和达特茅斯希区柯克医疗中心（DHMC）的教师。与此 为了扩大研究人员的基础，第三阶段COBRE奖将提供资源，以建立所需的 基础设施，以维持COBRE-CIR，进一步发展该计划，并促进跨学科的基本 转化免疫学研究。这一基础设施将包括继续指导 发展我们的免疫学能力，特别是那些以前由COBRE支持的研究人员; COBRE核心的扩展及其与现有互补核心的完全集成， DMS/DHMC的服务，特别是诺里斯棉花癌症中心和其他免疫学和“肺” 达特茅斯和佛蒙特大学的生物学”COBREs;以及一个增强的试点项目计划 以指导、协作和/或翻译/人类系统研究为目标。连同 移民管理局/人权监察委员会的实质性机构承诺，有信心， 调查人员已经通过COBRE机制得到了扩展和成熟，可以进一步发展， 完成一个可持续的免疫学研究中心的形成，该中心以优秀的 基础科学研究，包括一个转化的方法，以促进双向的板凳到床边 这是一个假设驱动的研究的应用，并具有区域性，如果不是也是国家性的影响。

Based on the success ofthe initial 10-year award, the ultimate goals of this COBRE renewal application are to complete the establishment at Dartmouth of a nationally recognized Center for Molecular, Cellular, and Translational Immunological Research, and to transition this COBRE Center for Immunological Research (COBRE-CIR) to an infrastructure-based, freestanding (from COBRE funding), sustainable center in five years. With the foundation of a long-standing Immunology Program, which has now been substantially enhanced by COBRE support, this proposal takes advantage of a highly interactive core of collaborative faculty at Dartmouth Medical School (DMS) and Dartmouth Hitchcock Medical Center (DHMC). With this expanded investigator base, a Phase III COBRE award will provide the resources to build the needed infrastructure to sustain the COBRE-CIR, further grow the Program, and facilitate inter-disciplinary basic science to translational immunological research. This infrastructure will include the continued mentored development of our immunlogical faculty, especially those investigators previously supported by COBRE; expansion ofthe COBRE Cores and their full integration with existing complementary cores and shared services at DMS/DHMC, particularly the Norris Cotton Cancer Center and the other Immunology and "Lung Biology" COBREs at Dartmouth and the Univesrity of Vermont; and an enhanced Pilot Projdect Program with targeting to mentored, collaborative, and/or translational/human systems research. Together with substantive Institutional commitment by DMS/DHMC, there is confidence that the strong existing cadre of investigators, already expanded and matured by the COBRE mechanism, can be further developed to complete the formation of a sustainable Center for Immunological Research that is grounded in excellent basic science investigation, embraces a translational approach to promote bidirectional bench-to-bedside application of hypothesis-driven research, and has a regional, if not also national, impact.