Training Program in HIV Cure

这项艾滋病毒治疗培训计划(TPHC)的目标是在基础、翻译、 面向优秀博士生和高素质医学博士研究生的HIV治疗议程和临床研究 或者博士后研究员。该项目包括来自8个博士项目的14名培训员和8名初级培训员，11名 医学院、勒纳医学院、牙医学院和 凯斯西储大学文理学院和两所大学的9个临床单位 医院(UH)病例医疗中心、路易斯斯托克斯克利夫兰退伍军人医疗中心和克利夫兰诊所 基金会，并与CASE/UH艾滋病研究中心(CFAR)密切合作。参赛的14人 资深教员以其卓越的研究能力、充足的国立卫生研究院和基金会的资金以及强有力的研究而闻名。 空间，并特别从非常多的优秀CFAR成员中挑选出来，以 专注于治愈外周、粘膜和大脑中的艾滋病毒感染这一单一目标。至 扩大我们培训人员的多样性，展望未来，我们还招聘了8名初级教师，拥有强大的 开发的程序还没有培训过很多调查人员，但将发展成为杰出的教官 通过我们的共同辅导计划。培训的重点是将分子和细胞的基本方法联系起来 病毒学、基因组学、蛋白质组学和系统生物学、免疫学和非艾滋病的临床解剖 机械问题和解决方案的复杂性，解决病毒库、持久性、延迟、 免疫衰竭、全身性炎症和免疫控制，特别强调(A)病毒 转录调控，(B)寄主限制因子，(C)病毒复制和储存，(D)系统性和 粘膜免疫，(E)临床试验，(F)信号转导和基因表达，(G)系统生物学和 生物信息学。博士前培训通过招收已入学的学生来完成 分子病毒学、细胞生物学、免疫学、系统生物学和生物信息学的8个博士项目， 化学、护理实践博士、分子医学、流行病学和生物统计学。最基本的 这些部门计划在三个部门提供的研究技能的课程作业和指导培训 健康科学校园的学校，克利夫兰临床基金会的勒纳医学院， 在艺术与科学学院，通过TPHC特定的组成部分进行补充和加强。 博士后实习生，通过招聘被任命到TPHC培训师实验室和CFAR，将 还参加下列方案和职业发展活动： (I)完成临床研究学者方案的额外必修研究生课程 (CRSP)中央水利部[http://casemed.case.edu/crsp] (Ii)参加大学艾滋病毒临床护理方面令人兴奋的临床沉浸体验 医院特殊免疫科，路易斯斯托克斯克利夫兰退伍军人医学中心 克利夫兰诊所基金会传染病科 (3)该大学在克利夫兰艾滋病毒社区行动委员会的代表 (Iv)前往乌干达坎帕拉与患者、科学家和临床医生进行国际旅行 联合临床研究中心[http://www.jcrc.org.ug]，，一个启动的卓越中心 约韦里·穆塞韦尼总统阁下于1990年处理#年非常严重的艾滋病毒/艾滋病问题 非洲 (V)与TPHC的其他受训人员和Fogarty建立一个由CFAR赞助的研究工作组 来自乌干达的学员在CWRU校园里 (6)在CFAR内部和外部年度务虚会上的来宾口头介绍，除了 每周系列研讨会和月刊俱乐部，由CFAR、全球研究中心组织 卫生部，传染病司，分子生物学和微生物学系， CCF的免疫学培训计划和分子医学计划 (Vii)由TPHC教员委员会提供指导，该委员会包括高级教员和初级教员，他们 正在开发艾滋病毒治疗研究前沿领域的独立项目 本申请申请4个职位(每年2名博士后和2名博士后或博士后)。

The goal of this Training Program in HIV Cure (TPHC) is to provide outstanding training in basic, translational, and clinical research toward the HIV Cure agenda to outstanding predoctoral students and highly qualified MD or PhD postdoctoral fellows. The program includes 14 trainers and 8 junior trainers from 8 PhD programs, 11 departments in the School of Medicine, the Lerner College of Medicine, School of Dental Medicine, and the College of Arts and Sciences at Case Western Reserve University, and 9 clinical units at both University Hospitals (UH) Case Medical Center, the Louis Stokes Cleveland VA Medical Center, and the Cleveland Clinic Foundation, and is closely allied with the Case/UH Center for AIDS Research (CFAR). The participating 14 senior faculty is known for excellence in research, ample NIH and foundation funding, and robust research space, and have been specifically selected from a very large complement of excellent CFAR members to provide focus toward the single goal of curing an HIV infection in the periphery, the mucosa, and the brain. To expand the diversity of our trainers and to look to the future, we have also recruited 8 junior faculty, with strong developing programs who have not yet trained many investigators, yet will develop into outstanding preceptors through our co-mentoring program. Training focuses on relating the basic approaches of molecular and cellular virology, genomics, proteomics and systems biology, immunology, and clinical dissection of non-AIDS complications to mechanistic questions and solutions that address viral reservoirs, persistence, latency, immune exhaustion, systemic inflammation, and immune control, with particular emphasis on (a) Viral transcriptional regulation, (b) Host restriction factors, (c) Viral replication and reservoirs, (d) Systemic and mucosal immunity, (e) Clinical trials, (f) Signal transduction and gene expression, and (g) Systems biology and bioinformatics. Predoctoral training is accomplished through enrollment of students who have matriculated in the 8 PhD programs in Molecular Virology, Cell Biology, Immunology, Systems Biology and Bioinformatics, Chemistry, Doctorate of Nursing Practice, Molecular Medicine, and Epidemiology and Biostatistics. The basic coursework and guided training in research skills provided by these departmental programs in the three schools on the Health Sciences Campus, at the Lerner College of Medicine in the Cleveland Clinic Foundation, and in the College of Arts and Sciences, is supplemented and enhanced by TPHC-specific components. Postdoctoral trainees, who are appointed via their recruitment to a TPHC trainer’s lab as well as the CFAR, will also participate in the following programmatic and career development activities: (i) Completion of an additional, required graduate course in the Clinical Research Scholars Program (CRSP) at CWRU [http://casemed.case.edu/crsp] (ii) Participation in an exciting Clinical Immersion Experience in HIV clinical care at the University Hospitals Special Immunology Unit, the Louis Stokes Cleveland VA Medical Center, or the HIV Section of the Department of Infectious Diseases at the Cleveland Clinic Foundation (iii) Representation of the University on the Cleveland HIV Community Action Board (iv) International travel to Kampala, Uganda to interact with patients, scientists, and clinicians at the Joint Clinical Research Center [http://www.jcrc.org.ug], a Center of of Excellence that was started by H.E. President Yoweri Museveni in 1990 to address the very serious problem of HIV/AIDS in Africa (v) Establishing a CFAR-sponsored research working team with other TPHC trainees and the Fogarty trainees from Uganda on the CWRU campus (vi) Guest oral presentations at the CFAR internal and external annual retreats, in addition to the weekly seminar series and monthly journal club, organized by the CFAR, the Center for Global Health, the Division of Infectious Diseases, the Department of Molecular Biology and Microbiology, the Immunology Training Program, and the Molecular Medicine Program at the CCF (vii) Mentoring by a TPHC faculty committee that includes senior trainers and junior trainer faculty who are developing independent programs in cutting-edge areas of HIV Cure research This application seeks 4 positions (2 predocs and 2 mid-career PhD or MD postdocs per year).