National Consortium on Alcohol and NeuroDevelopment in Adolescence: Admin

描述（由申请人提供）：作为对RFA-AA-12-006的回应，本申请建议由位于UCSD的全国青少年酒精和神经发育联盟（N-CANDA）的行政部门确定酒精使用对发育中的青少年大脑的影响。该联合会旨在提供具有全国代表性的青少年样本，并将不同的科学专门知识和研究经验与每个地点的研究人员所代表的青年相结合。因此，应联合考虑以下应用程序：N-CANDA：行政组件，UCSD（PI：Sandra Brown PhD（联系人），Susan Tapert PhD）N-CANDA：数据组件，SRI（PI：Adolf Pfefferbaum，M.D.） N-CANDA：杜克（PI：Michael DeBellis，医学博士） N-CANDA：匹兹堡（PI：邓肯克拉克博士，（医学博士） N-CANDA：SRI（PI：Ian Colrain，Ph.D.（联系人）和菲奥娜贝克，博士） N-CANDA：UCSD（PI：Susan Tapert，Ph.D.）招募年龄在12岁至21岁之间的680名受试者的高风险增强社区样本将完成基线评估，然后在加速纵向设计中进行三次年度随访评估。在每次访问时，将测量多模式MRI协议，综合神经心理电池，酒精使用和相关问题的评估，沿着其他物质参与，心理健康症状和其他风险因素。脑成像使用最先进的高分辨率结构MRI（sMRI）、扩散张量成像（DTI）、静息状态MRI（rsMRI）和抗扫视或Stroop功能性MRI任务，以利用当地的专业知识。酒精后果的检查将集中在结构和功能成熟的大脑区域，在青春期积极发展，参与心理调节，响应奖励，被认为是容易受到有毒酒精的影响。RFA中规定的五个目标将进行系统测试，重点是青少年物质使用和神经成熟轨迹。四个研究部分中的每一个都将与另一个网站合作实现两个额外的目标。在风险和基线大脑特征的背景下进行检查，我们将确定酒精暴露对青少年大脑发育轨迹的影响，并确定预先存在的心理生物学脆弱性，这些脆弱性可能会使青少年面临更大的酒精使用障碍风险。

DESCRIPTION (provided by applicant): In response to RFA-AA-12-006, this application proposes the Administrative Component of the National Consortium on Alcohol and Neurodevelopment in Adolescence (N-CANDA), located at UCSD, to determine the effects of alcohol use on the developing adolescent brain. This consortium was designed to provide a nationally representative sample of adolescents and to integrate the diverse scientific expertise and research experience with youth represented by researchers at each site. As such, the following applications should be considered jointly: N-CANDA: Administrative Component, UCSD (PI: Sandra Brown PhD (Contact), Susan Tapert PhD) N-CANDA: Data Component, SRI (PI: Adolf Pfefferbaum, M.D.) N-CANDA: Duke (PI: Michael DeBellis, M.D.) N-CANDA: Pittsburgh (PI: Duncan Clark, Ph.D., M.D.) N-CANDA: SRI (PIs: Ian Colrain, Ph.D. (Contact) and Fiona Baker, Ph.D.) N-CANDA: UCSD (PI: Susan Tapert, Ph.D.) Recruited at ages 12 through 21, a high-risk enhanced community sample of 680 subjects will complete a baseline assessment then undergo three annual follow-up assessments in an accelerated longitudinal design. At each visit, a multimodal MRI protocol, comprehensive neuropsychological battery, and assessment of alcohol use and related problems, along with other substance involvement, mental health symptoms, and other risk factors, will be measured. Brain imaging uses state-of-the-art high-resolution structural MRI (sMRI), diffusion tensor imaging (DTI), resting state MRI (rsMRI), and an anti-saccade or Stroop functional MRI task to capitalize on local expertise. The examination of alcohol consequences will focus on structural and functional maturation of brain areas that are actively developing during adolescence, involved in psychological regulation, responsive to rewards, and thought to be vulnerable to toxic alcohol effects. Five aims specified in the RFA will be systematically tested with a focus on adolescent substance use and neuromaturational trajectories. Each of the four Research Components will collaborate with another site on two additional aims. Examined in the context of risks and baseline brain characteristics, we will determine both the effects of alcohol exposure on the developmental trajectory of the adolescent human brain, and identify preexisting psychobiological vulnerabilities that may put an adolescent at greater risk for an alcohol use disorder.