Stem Cells and Cancer

 描述（由申请人提供）：要求支持由奥斯汀格尼，康妮J伊夫斯和简E。维斯维德会议将于2016年3月6日至11日在科罗拉多州布雷肯里奇举行。癌症干细胞现在已经在各种各样的人类肿瘤中被认识到。癌症干细胞的存在对我们成功对抗癌症的能力既提出了巨大的挑战，也带来了诱人的潜力。本次会议旨在汇集有兴趣更好地了解癌症干细胞促进肿瘤异质性，自我更新和耐药性的机制的科学家。其中一个重点领域将是细胞间通讯。细胞环境和微环境建立肿瘤生态位，并塑造肿瘤与免疫系统的相互作用。此外，发育信号转导途径，如Hippo，Notch和Wnt，在癌症中经常失调，越来越多地为治疗干预提供了切实的机会。另一个重要的重点领域将是努力更好地了解肿瘤异质性的机制和重要性。克隆分析和条形码等技术为肿瘤进化、分化、miRNA控制和表观遗传学之间的相互作用提供了重要的线索。这是一个在理解癌症干细胞生物学方面取得快速进展的时代，具有巨大的潜力，有益于人类健康，这是一个与国家癌症研究所的使命明确相关的主题。

 DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Stem Cells and Cancer, organized by Austin Gurney, Connie J. Eaves and Jane E. Visvader. The meeting will be held in Breckenridge, Colorado from March 6-11, 2016. Cancer stem cells have now been recognized in a wide variety of human tumors. The existence of cancer stem cells poses both tremendous challenges and tantalizing potential for our ability to successfully combat cancer. This meeting aims to bring together scientists who are interested in better understanding the mechanisms by which cancer stem cells contribute to tumor heterogeneity, self-renewal and drug resistance. One area of emphasis will be intercellular communication. Cellular context and microenvironment establish the tumor niche and shape the interaction of the tumor with the immune system. In addition, developmental signal transduction pathways such as Hippo, Notch and Wnt, frequently deregulated in cancer, increasingly offer tangible opportunities for therapeutic intervention. Another important area of emphasis will be efforts to better understand the mechanisms and importance of tumor heterogeneity. Techniques such as clonal analysis and barcoding are shedding important light on the interplay between tumor evolution, differentiation, miRNA control and epigenetics. This is an era of rapid progress in understanding cancer stem cell biology with great potential to benefit human health, and it is a topic of clear relevance to the mission of the National Cancer Institute.