MEASUREMENT OF BIOSPECIMENS IN THE EAGeR TRIAL

AIGHER试验是一项多中心、随机、双盲、安慰剂对照试验，在美国的四个医学中心进行。阿司匹林的妊娠和生殖效果(AGRGE)试验是一项多点、前瞻性的双盲随机对照试验，旨在评估小剂量阿司匹林与叶酸联合治疗对1228名有1-2次减孕史的妇女的妊娠和妊娠的影响。有一个大型的生物样品库可供分析，并为测试多个假说提供了一个很好的平台。这项提议是通过生物医学IDIQ机制申请资金，用于在紧急试验中测量储存的生物样本。建议的化验将提供丰富的生物标记物水平的数据源，可以结合急切试验中已经收集的大量数据进行分析，以回答新的研究问题。

The EAGeR trial was a multi-center, block-randomized, double-blind, placebo-controlled trial conducted across four medical centers in the U.S. The Effects of Aspirin in Gestation and Reproduction (EAGeR) Trial is a multi-site, prospective double-blind randomized controlled trial designed to assess the effects of low-dose aspirin in combination with folic acid treatment on pregnancy and gestation among 1228 women with a history of 1-2 pregnancy losses. A large biospecimens repository is available for analysis and offers a good platform for testing multiple hypotheses. This proposal is to request funding through the Biomedical IDIQ mechanism for the measurement of stored biospecimens in the EAGeR Trial. The assays proposed will provide a rich data source on biomarker levels that can be analyzed to answer novel research questions in conjunction with the extensive data already collected in the EAGeR Trial.