Enriching the Rhode Island Child Health Study

项目总结/摘要 拟议项目是响应RFA-ES-16-004“维护和 丰富现有环境流行病学队列的资源基础设施。”我们建议 维护和丰富罗得岛儿童健康研究（RICHS）的资源基础设施， 研究环境对新生儿和幼儿健康结果的影响， 新的重点是胎盘分子功能的机制作用。RICHS是一个高产群体 迄今为止，资源数据收集和分析已产生40多份同行评审出版物， 自2008年以来的研究项目赠款（R 01 MH 094609，R 01 ES 022223，R 01 ES 025145）; RICHS还 作为21名博士前和博士后的培训和独立研究发展的资源 学生和初级教师。来自队列的数据和结果有助于理解 胎盘的基础分子生物学，环境暴露对胎盘表观遗传的影响 调节，新生儿生长中胎盘表观遗传变异与神经行为结果之间的联系， 以及新方法的开发。RICHS队列由840对母子组成， 罗得岛和马萨诸塞州东南部地区从一个单一的、具有人口代表性的 医学中心RICHS后代在婴儿期就被研究，但纵向研究需要维持资金。 随访拟议的基础设施支助将促进未来的前瞻性纵向评估 在这个广泛表征的产前队列中，包括新的儿童健康和疾病结果， 出生后的环境暴露，以及分子介质的新的和重复的措施， 在儿童期和青春期早期易感性的关键窗口期间的生物标志物。拟议 基础设施支持还将允许与更大的科学机构广泛共享RICHS数据。 社区本R24的具体目标是：（1）重新联系并重新同意所有RICHS母子对， 允许继续和扩大后续行动，（2）开发一个创新的网站，用于队列维护， 建立群组社区，（3）开发一个基于网络的数据收集系统， REDCap，（4）为维持参与者在RICHS的投资提供持续的激励措施，（5）收集医疗费用 记录，神经发育措施和生物标本，用于未来的研究，和（6）开发系统 与更大的研究社区广泛共享队列数据。我们的研究符合NIEHS的目标， 基本的共享机制，以考虑人类暴露的总体情况，生物途径， 疾病的发病机理，促进合作，并激励新的环境卫生科学家骨干。 最终，拟议的RICHS基础设施支持将最大限度地提高NIEHS在一个独特的 队列资源，使我们的高产研究小组和广泛的 与科学界分享数据和资源。

PROJECT SUMMARY/ABSTRACT The proposed project is an R24 infrastructure support grant responsive to RFA-ES-16-004, “Maintain and Enrich Resource Infrastructure for Existing Environmental Epidemiology Cohorts.” We propose to maintain and enrich resource infrastructure for the Rhode Island Children's Health Study (RICHS), a cohort developed to examine the impact of the environment on newborn and early childhood health outcomes with a novel focus on the mechanistic role of placenta molecular function. RICHS is a highly productive cohort resource—data collection and analyses to date have resulted in over 40 peer-reviewed publications, and 3 research project grants since 2008 (R01MH094609, R01ES022223, R01ES025145); RICHS has also served as a resource for the training and independent research development of 21 pre- and postdoctoral students and junior faculty. Data and results from the cohort have contributed to the understanding of the fundamental molecular biology of the placenta, the impact of environmental exposures on placental epigenetic regulation, links between placental epigenetic variation in newborn growth and neurobehavioral outcomes, as well as novel methods development. The RICHS cohort is comprised of 840 mother-offspring pairs from the Rhode Island and Southeastern Massachusetts region enrolled from a single, population-representative medical center. RICHS offspring were studied in infancy, but maintenance funds are needed for longitudinal follow-up. The proposed infrastructure support would facilitate future prospective, longitudinal assessments within this extensively characterized prenatal cohort, including novel child health and disease outcomes, postnatal environmental exposures, as well as novel and repeated measures of molecular mediators and biomarkers during the critical window of susceptibility of childhood and early adolescence. The proposed infrastructure support will also allow extensive resource-sharing of RICHS data with the larger scientific community. The specific goals of this R24 are to: (1) recontact and reconsent all RICHS mother-child pairs to allow for continued and expanded follow-up, (2) develop an innovative website for cohort maintenance and cohort community building, (3) develop a web-based data collection system for ongoing data collection using REDCap, (4) provide ongoing incentives for maintaining participant investment in RICHS, (5) collect medical record, neurodevelopmental measures and biospecimens for future research studies, and (6) develop systems for broad sharing of cohort data with the larger research community. Our study fits with NIEHS goals to identify fundamental shared mechanisms, to consider the totality of human exposures, biological pathways, and disease pathogenesis, to foster collaboration, and to inspire new cadre of environmental health scientists. Ultimately, the proposed RICHS infrastructure support will maximize NIEHS investment in a unique cohort resource to allow for further seminal work from our highly productive research group and broad sharing of data and resources with the scientific community.