Exposure Core

抽象-曝光核心 强有力的暴露评估是任何环境流行病学或毒理学项目成功的关键。 暴露在有机化学品和空气污染物中已被认为与不良神经系统有关， 呼吸健康，免疫系统，内分泌和代谢调节结果，主题领域 这个中心。确定接触是复杂的，因为人们通过多种途径接触到多种化合物 暴露途径。此外，营养状况已被证明与接触化学物质有交互作用，因此 还必须将其作为有影响力的暴露和环境卫生项目中的辅助因素进行评估。 鉴于评估接触化合物的高度复杂性，目前对 流行病学和毒理学研究，需要一个多学科团队来设计暴露 评估、收集和分析数据，并解释结果。曝光核心的首要目标 提供暴露研究设计和分析专业知识，以提高需要暴露研究的质量 评估加州大学戴维斯分校进行的环境健康研究的质量。这是 通过三个机制来完成。首先，一个设计团队将举办曝光设计诊所，包括 PIS、暴露科学家、分析化学家和生物统计学家。PIE将他们项目的目标介绍给 设计团队和团队与绩效指标合作，设计适当且具有成本效益的暴露研究。 其次，我们为调查人员提供了收集和分析暴露样本的资源，包括 在以下方面有专长的实验室：环境和环境中有机化合物的目标和非目标分析 生物样品，时间积分模拟暴露浓度，收集的空气的成分分析 污染和其他环境样品，包括功能有机基团和各种元素和 通过XRF和ICPMS分析的同位素，动物吸入毒理学研究的设计指南 使用一系列空气污染物，并通过问卷或生物标记物了解营养状况。第三, 我们将为调查人员提供帮助，解释他们的暴露评估数据，方法是 相关科学家向项目团队陈述他们的结果，并协助PI解释数据和 将它们与研究期间获得的健康结果联系起来。通过提供暴露评估专业知识来 调查人员作为综合核心的一部分，而不是通过独立的校园实验室，我们将能够 通过我们的协同效应提供更加强大、适当和定制的风险敞口评估， 互动和协作。此外，暴露核心将与综合健康密切协调 科学设施核心，以优化研究的总体设计，既包括曝光，也包括 生物标记物或疾病评估，从而确保在所有层面上健全的科学。

Abstract - Exposure Core A robust exposure assessment is key to the success of any environmental epidemiology or toxicology project. Exposures to organic chemicals and air pollutants have been implicated in adverse Nervous System, Respiratory Health, Immune System, and Endocrine and Metabolic Regulation outcomes, the theme areas of this Center. Determining exposure is complex as people are exposed to multiple compounds through multiple exposure pathways. Additionally, nutritional status has been shown to interact with chemical exposures so must also be assessed both as an influential exposure and as a cofactor in environmental health projects. Given the high degree of complexity for assessing exposure to compounds presently of high interest in epidemiological and toxicological studies, a multidisciplinary team is needed to design the exposure assessment, collect and analyze the data, and interpret the results. The overarching goal of the exposure core is to provide exposure study design and analysis expertise to improve the quality of studies requiring exposure assessment, and by extension, the quality of environmental health research conducted at UC Davis. This is accomplished through three mechanisms. First, a Design Team will hold Exposure Design Clinics that include PIs, exposure scientists, analytical chemists, and biostatisticians. PIs present the aims of their projects to the design team and the team works with the PIs to design appropriate and cost-effective exposure studies. Second, we provide investigators with resources to collect and analyze exposure samples by including laboratories with expertise in: target and non-target analysis of organic compounds in environmental and biological samples, time integrated modeled exposure concentrations, compositional analysis of collected air pollution and other environmental samples, including functional organic groups, and various elements and isotopes through XRF and ICPMS analysis, guidance for the design of animal inhalation toxicology studies using a range of air pollutants, and nutritional status through either questionnaires or biological markers. Third, we will provide investigators with assistance in interpreting their exposure assessment data by bringing the relevant scientists to the project team presenting their results, and assisting the PI in interpreting the data and relating them to health outcomes obtained during the study. By providing exposure assessment expertise to investigators as part of an integrated core, rather than via independent campus laboratories, we will be able to provide a much more robust, appropriate, and custom tailored exposure assessment through our synergies, interactions and collaborations. Moreover, the Exposure Core will coordinate closely with the Integrative Health Sciences Facility Core so as to optimize the overall design of the study with respect to both the exposure and biomarker or disease assessments and to thereby ensure sound science at all levels.