Support of Yerkes National Primate Research Center

 描述（由申请人提供）：本申请寻求埃默里大学耶基斯国家灵长类动物研究中心的P51基础赠款（OD 011132）的五年持续支持。耶基斯的总体目标是通过提供适当的科学和兽医专业的资源基础设施和专业知识，开展一项研究计划，重点关注与人类健康和NIH使命相关的科学问题，并确保 中心作为核心科学家以及区域、国家和国际科学家的资源的能力。在本报告所述期间（2011年5月1日至今），耶基斯中心取得了显著进展，许多（>790）出版物证明了这一点，新的动物设施的建设，包括最先进的移植ad ABSL 3设施，以及其研究资金基础的逐步扩大，即使在竞争激烈的NIH资助环境的时代。此外，耶基斯灵长类动物中心一直保持着出色的核心研究计划，并提供资源和服务，以广泛的多学科网络的附属机构和合作研究人员在整个地区和国家。这些研究项目涉及使用各种非人类灵长类动物物种，主要针对四个主要研究学科，代表耶基斯中心内的研究部门：1）微生物学和免疫学; 2）发育和认知神经科学; 3）神经药理学和神经疾病; 4）行为神经科学和精神疾病。此外，通过动物资源和病理学的部门，耶基斯提供支持外部调查人员进行研究在耶基斯中心，符合我们的ORIP授权的作用，作为一个区域和国家的资源。未来支持期的具体目标包括：1）利用非人灵长类动物开展基础和转化研究，以扩大知识，开发更好的治疗方法，并促进造福人类的治疗方法; 2）提供区域和国家资源，以获得数据，咨询专业知识，生物材料和专用设施，以支持非人灵长类动物研究; 3）研究基本的非人灵长类动物生物学，改善非人灵长类动物的繁殖，饲养和遗传特性，以更好地服务于生物医学研究界;和4）提供研究和培训机会，涉及非人灵长类动物的研究生和本科生，博士后研究员，访问科学家和教职员工。追求这些目标将提高中心的能力，作为核心和附属科学家进行非人类灵长类动物研究的有利资源，所有这些都是为了促进人类健康的最终目标。

 DESCRIPTION (provided by applicant): This application seeks five years of continued support for the P51 Base Grant (OD 011132) for the Yerkes National Primate Research Center of Emory University. The overarching goals of Yerkes are to conduct a research program focused on scientific problems relevant to human health and the NIH mission by providing resource infrastructure and expertise in appropriate scientific and veterinary specialties and to ensure the Center's ability to serve as a resource to Core Scientists, as well as to scientists regionally, nationally and internationally. During the current reporting period (5/1/2011 to present), the Yerkes Center has recorded remarkable progress, as evidenced by numerous (>790) publications, construction of new animal facilities, including a state-of-the-art transplantation ad ABSL3 facility, and progressive expansion of its research funding base, even in the era of an extremely competitive NIH funding environment. In addition, the Yerkes Primate Center has maintained outstanding core research programs and provided resources and services to a broad multidisciplinary network of affiliate and collaborative investigators throughout the region and nation. These research programs, which involve the use of a variety of nonhuman primate species, are directed primarily toward four major research disciplines, representing the research divisions within the Yerkes Center: 1) Microbiology and Immunology; 2) Developmental and Cognitive Neuroscience, 3) Neuropharmacology and Neurologic Diseases and 4) Behavioral Neuroscience and Psychiatric Disorders. Also, through the Divisions of Animal Resources and Pathology, Yerkes provides support for outside investigators conducting research at the Yerkes Center, consistent with our ORIP-mandated role as a regional and national resource. Specific aims for the upcoming period of support include: 1) To carry out basic and translational research using nonhuman primates to expand knowledge, develop improved treatments, and advance cures that will benefit humanity; 2) To provide regional and national resources for data, consultative expertise, biologic materials, and specialized facilities useful in supporting nonhuman primate research; 3) To study basic nonhuman primate biology and improve nonhuman primate breeding, husbandry and genetic characterization to better serve the biomedical research community; and 4) To provide research and training opportunities involving nonhuman primates to graduate and undergraduate students, postdoctoral fellows, visiting scientists and faculty members. The pursuit of these aims will enhance the Center's ability to serve as an enabling resource to Core and Affiliate Scientists for the conduct of nonhuman primate research, all for the ultimate goal of advancing human health.