Dartmouth Cystic Fibrosis Training Program

在本应用程序中，我们提出了达特茅斯囊性纤维化培训计划(DCFTP)来培训下一位 一代研究囊性纤维化的生物学和后遗症的研究人员。寻求支持的是 全面、互动性强的跨部门培训计划，重点是CF 跨膜电导调节因子(CFTR)转运和宿主-病原菌相互作用 参见在请求支持的5年期间，我们预计将有12名合格后考试、博士前 学生接受最长2年的培训支持。我们的节目汇集了 来自广泛部门的敬业调查人员(我们目前的计划包括 生物化学、化学、遗传学、医学、微生物学/免疫学、流行病学、 儿科学和工程学)为博士生和医学博士/博士生提供与CF相关的研究指导。在……里面 在这份意见书中，我们建议直接支持四名博士前研究员。最近更名的达特茅斯 囊性纤维化培训计划将在研究基地的背景下发挥作用，该基地已经拥有丰富的基础、 翻译和临床与慢性肾功能衰竭相关的研究。达特茅斯大学的CF研究项目已经从三个 研究人员和NIH在1997年向一个世界级科学家社区提供的一笔赠款，该社区目前确保 总计6,990万美元的研究资助总成本(直接和间接)。我们的节目有14个人参加 培训学院在一系列学科中工作，以CF研究为中心；所有培训学院 进行研究，有充足的资金，并教导和指导我们的实习生。这群基础--和内科-- 科学家研究人员积极从事CF相关研究，具有细胞生物学、结构生物学等方面的专长 生物学、微生物学、免疫学、遗传学、生物信息学、统计学、计算生物学和 蛋白质组学。作为开发这一计划的一部分，两门新课程和一个暑期生物信息学研讨会 都是由培训学院开发的，一个新的杂志俱乐部已经成立，一个联合互动小组 会议已经确定，年度务虚会已经扩大到包括学术和 来自东北、美国和世界各地的制药/生物技术科学家。培训-赠款资金和 DCFTP赞助的、针对学员的增强活动提供了一个统一的基础，极大地促进了 这一群体具有显著的互动性(过去5年的24份合作出版物证明了这一点 在我们的培训和附属教职员工中)，以及这些教职员工所持有的合作助学金。本计划 建立在达特茅斯研究CF的研究人员的历史优势之上。

In this application, we propose the Dartmouth Cystic Fibrosis Training Program (DCFTP) to train the next generation of researchers studying the biology and sequelae of cystic fibrosis (CF). Support is sought for a comprehensive, highly interactive, interdepartmental training program, with an emphasis on CF transmembrane conductance regulator (CFTR) trafficking and host-pathogen interactions in the context of CF. During the 5 year period of the requested support, we anticipate 12 post-qualifying exam, predoctoral students receiving a maximum of 2 years of training support. Our program has pooled the talents of dedicated investigators from a wide range of departments (our current program includes faculty in the departments of Biochemistry, Chemistry, Genetics, Medicine, Microbiology/Immunology, Epidemiology, Pediatrics, and Engineering) to provide instruction in CF-related research to PhD and MD/PhD students. In this submission, we propose to directly support four predoctoral fellows. The recently re-named Dartmouth Cystic Fibrosis Training Program will function in the context of a Research Base already rich in basic, translational, and clinical CF-related studies. The CF research program at Dartmouth has grown from three investigators and one NIH grant in 1997 to a community of world-class scientists that currently secures $69.9M in aggregate total (direct plus indirect) costs of research funding. Our program has 14 participating Training Faculty working in a range of disciplines, with CF research as the central focus; all Training Faculty conduct research, are well funded, and teach and mentor our Trainees. This group of basic- and physician- scientist researchers is actively engaged in CF-related research, with expertise in cell biology, structural biology, microbiology, immunology, genetics, bioinformatics, statistics, computational biology and proteomics. As part of developing this program, two new courses and a summer bioinformatics workshop have been developed by Training Faculty, a new Journal Club has been instituted, a joint interactive group meeting has been established, and the yearly retreat has been expanded to include academic and pharma/biotech scientists from across the Northeast, the US and the world. Training-grant funds and DCFTP-sponsored, Trainee-specific enhanced activities provide a unifying base that greatly facilitates the strikingly interactive nature of this group (evidenced by 24 collaborative publications in the last 5 years among our Training and Affiliated faculty) and the collaborative grants held by these faculty. This Program builds on the historical strengths of the investigators at Dartmouth studying CF.