1/1 NADIA Administrative Core

描述（由申请人提供）：这是成年期青少年饮酒神经生物学（NADIA）管理核心（NADIA管理核心-U24，RFA-AA-15-005）的更新。行政核心提供行政和科学领导，以实现我们的联盟的目标：阐明青少年酒精暴露后复杂的大脑功能-行为关系的持续变化。在之前的资助期间，NADIA发现青少年间歇性乙醇（AIE）导致成年后的多种病理，包括改变焦虑，社会行为，认知灵活性，冲突行为，睡眠，冲动，决策，激励显着性，成年饮酒增加和对酒精的反应降低，以及改变神经免疫基因表达，神经发生，表观遗传组蛋白甲基化变化，并降低胆碱乙酰转移酶表达。为了促进和促进这一进展，NADIA行政核心是联盟的主要组织单位，并作为八个研究部门，两个科学核心，NIAAA，NADIA指导委员会和外部咨询委员会之间的联络。该核心组织所有联盟活动，包括务虚会，进度报告和核心和组件的外部咨询委员会评估。行政核心通过促进各组成部分和核心之间的沟通和数据整合，确保取得一致和向前的进展。核心开发科学和概念主题以及跨组件的标准操作程序。核心数据库提供了NADIA所有出版物（在提交时，上一个资助期已出版或正在印刷的出版物有119种）和联盟生成的数据的存储库。最后，该核心还促进了NADIA生成数据的传播和翻译。了解未成年人饮酒对成人神经生物学的影响对于指导公共卫生举措非常重要，NADIA行政核心为整个联盟的此类发现创造了协同效应。

DESCRIPTION (provided by applicant): This is the renewal of the Neurobiology of Adolescent Drinking in Adulthood (NADIA) Administrative Core (NADIA Administrative Core-U24, RFA-AA-15-005). The Administrative Core provides administrative and scientific leadership to achieve the goal of our Consortium: to elucidate persistent changes in complex brain function-behavior relationships following adolescent alcohol exposure. In the previous funding period, the NADIA discovered that adolescent intermittent ethanol (AIE) led to multiple pathologies in adulthood, including altered anxiety, social behavior, cognitive flexibility, conflict behavior, sleep, impulsivity, decision making, incentive salience, increased adult alcohol drinking and decreased response to alcohol, as well as altered neuroimmune gene expression, neurogenesis, epigenetic histone-methylation changes, and decreased choline acetyltransferase expression. To promote and facilitate this progress, the NADIA Administrative Core is the main organizational unit of the Consortium and serves as the liaison between the eight Research Components, the two Scientific Cores, the NIAAA, the NADIA Steering Committee, and the External Advisory Board. This Core organizes all Consortium activities including retreats, progress reports and External Advisory Board evaluations of cores and components. The Administrative Core ensures consistent and forward progress by facilitating communication and promoting integration of data among the components and cores. The Core develops scientific and conceptual themes as well as standard operating procedures that cross components. The Core provides a repository for all NADIA publications (at the time of submission, 119 publications were published or in press from the previous funded period) and data generated by the Consortium. Finally, the Core facilitates dissemination and translation of NADIA-generated data. Understanding the impact of underage drinking on adult neurobiology is important to guide public health initiatives, and the NADIA Administrative Core creates synergies for such discoveries across the Consortium.