Enriching the Rhode Island Child Health Study

项目摘要/摘要 拟议的项目是响应RFA-ES-16-004的R24基础设施支助赠款，“维护和 丰富现有环境流行病学队列的资源基础设施。我们建议 维护和丰富罗德岛儿童健康研究(RICHS)的资源基础设施，这是一个队列 研究环境对新生儿和儿童早期健康结果的影响 新的重点是胎盘分子功能的机制作用。RICHS是一个高生产率的群体 资源数据收集和分析迄今已产生40多份经同行审查的出版物和3份 2008年以来的研究项目拨款(R01MH094609，R01ES022223，R01ES025145)；RICHS还 作为21名博士后和博士后培训和自主研究发展的资源 学生和初级教职员工。来自队列的数据和结果有助于理解 胎盘的基础分子生物学，环境暴露对胎盘表观遗传学的影响 调节，新生儿生长中胎盘表观遗传变异与神经行为结果之间的联系，如 以及新方法的开发。RICHS队列由840对来自 罗德岛和马萨诸塞州东南部地区从一个单一的人口代表登记 医疗中心。RICHS的后代是在婴儿时期进行研究的，但纵向研究需要维护资金 后续行动。拟议的基础设施支持将促进未来的前瞻性、纵向评估 在这一具有广泛特征的产前队列中，包括新的儿童健康和疾病结果， 出生后环境暴露，以及新的和重复的分子介质和 儿童和青春期早期易感的关键窗口中的生物标志物。建议数 基础设施支持还将允许RICHS数据与更大的科学 社区。R24的具体目标是：(1)重新联系并重新同意所有RICHS母婴配对 考虑到持续和扩大的后续行动，(2)开发一个用于队列维护和创新的网站 队列社区建设，(3)开发基于网络的数据收集系统，用于持续数据收集，使用 RedCap，(4)为保持参与者对RICHS的投资提供持续激励，(5)收集医疗 用于未来研究的记录、神经发育测量和生物标本，以及(6)开发系统 与更大的研究社区广泛共享队列数据。我们的研究符合NIEHS的目标，即 基本的共享机制，以考虑人类暴露的总体、生物途径和 疾病发病机制，促进协作，并激励环境卫生科学家的新干部。 最终，拟议的RICHS基础设施支持将使NIEHS在一个独特的 分配资源，以便我们高效的研究小组和广泛的 与科学界共享数据和资源。

PROJECT SUMMARY/ABSTRACT The proposed project is an R24 infrastructure support grant responsive to RFA-ES-16-004, “Maintain and Enrich Resource Infrastructure for Existing Environmental Epidemiology Cohorts.” We propose to maintain and enrich resource infrastructure for the Rhode Island Children's Health Study (RICHS), a cohort developed to examine the impact of the environment on newborn and early childhood health outcomes with a novel focus on the mechanistic role of placenta molecular function. RICHS is a highly productive cohort resource—data collection and analyses to date have resulted in over 40 peer-reviewed publications, and 3 research project grants since 2008 (R01MH094609, R01ES022223, R01ES025145); RICHS has also served as a resource for the training and independent research development of 21 pre- and postdoctoral students and junior faculty. Data and results from the cohort have contributed to the understanding of the fundamental molecular biology of the placenta, the impact of environmental exposures on placental epigenetic regulation, links between placental epigenetic variation in newborn growth and neurobehavioral outcomes, as well as novel methods development. The RICHS cohort is comprised of 840 mother-offspring pairs from the Rhode Island and Southeastern Massachusetts region enrolled from a single, population-representative medical center. RICHS offspring were studied in infancy, but maintenance funds are needed for longitudinal follow-up. The proposed infrastructure support would facilitate future prospective, longitudinal assessments within this extensively characterized prenatal cohort, including novel child health and disease outcomes, postnatal environmental exposures, as well as novel and repeated measures of molecular mediators and biomarkers during the critical window of susceptibility of childhood and early adolescence. The proposed infrastructure support will also allow extensive resource-sharing of RICHS data with the larger scientific community. The specific goals of this R24 are to: (1) recontact and reconsent all RICHS mother-child pairs to allow for continued and expanded follow-up, (2) develop an innovative website for cohort maintenance and cohort community building, (3) develop a web-based data collection system for ongoing data collection using REDCap, (4) provide ongoing incentives for maintaining participant investment in RICHS, (5) collect medical record, neurodevelopmental measures and biospecimens for future research studies, and (6) develop systems for broad sharing of cohort data with the larger research community. Our study fits with NIEHS goals to identify fundamental shared mechanisms, to consider the totality of human exposures, biological pathways, and disease pathogenesis, to foster collaboration, and to inspire new cadre of environmental health scientists. Ultimately, the proposed RICHS infrastructure support will maximize NIEHS investment in a unique cohort resource to allow for further seminal work from our highly productive research group and broad sharing of data and resources with the scientific community.