Training Program in Molecular Medicine

项目摘要 2006年，耶鲁大学启动了创新的医学研究学者计划（MRSP），其使命是 提供广泛而深入的博士学位。分子生物学，细胞生物学， 生物化学、遗传学、生理学、药理学和病理学，结合密集暴露于 医学导向的课程和指导的临床经验，专为博士设计。学生的 这种培训的最终目标是准备我们的学生成为未来的跨学科领导者在生物医学 科学，具有独特的能力，追求临床相关的基础科学调查，旨在 阐明疾病的分子机制。直到获得NIGMS T32的前五年支持 我们现在正在寻求延长，MRSP得到了机构基金和基金的支持， 由霍华德休斯医学研究所（HHMI）提供。2013-2014年后终止对人力资源管理和人力资源部的支持 学年，并希望继续这一非常成功的正在进行的计划构成的理由， 申请这项分子医学（MM）培训补助金的第一个五年奖，该补助金支持了四个 每年的实习生名额。耶鲁大学支持生物医学科学的所有一年级博士生，因此 这个T32每年支持两个二年级和两个三年级的学生。MRSP学生参加一个 各种各样的计划活动，旨在从事博士。医学相关培训和经验的学生 在他们的研究生学习中。这些课程首先关注正常的人体生理学，基于器官的细胞 生物学和生物统计学，其次是人类病理生物学和药物发现，验证， 和临床试验。MRSP学生还可以选择与耶鲁大学医学博士一年级学生一起参加 每周一次的小组生理学“病例会议”辅导，他们在其中深入探讨了生理学 特定疾病状态的基础。MRSP的基石是一个为期两年的指导临床 经验，为学生提供深入接触人类疾病背后的科学和第一手资料， 与患者的纵向接触，以一种不 通过传统的课堂学习。除了这些正式活动外，MRSP还提供 就选择论文研究实验室和组装 论文委员会，以支持NIGMS分子医学计划的目标，提供培训， 基础生物医学科学，重点是阐明人类疾病的机制。基于伟大的 要求进入MRSP由优秀的培训补助金合格的学生已经录取， 耶鲁大学的生物医学博士项目，我们要求增加每年的名额 从四年级增加到六年级，这将使我们每年能够支持三名二年级和三名三年级的学生。

PROJECT SUMMARY In 2006 Yale started the innovative Medical Research Scholars Program (MRSP) with the mission of providing broad and deep Ph.D. training in the core basic science concepts of molecular biology, cell biology, biochemistry, genetics, physiology, pharmacology, and pathology, integrated with intensive exposure to medically oriented coursework and mentored clinical experiences designed specifically for Ph.D. students. The ultimate goal of this training is to prepare our students to be future interdisciplinary leaders in the biomedical sciences, with a unique ability to pursue clinically relevant fundamental basic science inquiry aimed at elucidating the molecular mechanisms of disease. Until the award of the first five years of NIGMS T32 support that we are now seeking to renew, MRSP had been supported by a combination of institutional funds and funds provided by the Howard Hughes Medical Institute (HHMI). Termination of HHMI support after the 2013-2014 academic year, and the desire to continue this highly successful ongoing program constituted the rationale for applying for the first five-year award of this Molecular Medicine (MM) Training Grant, which supported four trainee slots per year. Yale University supports all first-year PhD students in the biomedical sciences, and thus this T32 supports two second-year and two thrid-year students each year. MRSP students participate in a variety of program activities designed to engage Ph.D. students in medically relevant training and experiences throughout their graduate studies. The classes focus first on normal human physiology, organ-based cell biology, and biostatistics, followed by human pathobiology and an introduction to drug discovery, validation, and clinical trials. MRSP students also have the option to participate with first-year Yale MD students in weekly small-group physiology “case conference” tutorials, in which they explore in depth the physiological underpinnings of particular disease states. The cornerstone of the MRSP is a two-year mentored clinical experience that provides students with in-depth exposure to the science behind human diseases and first-hand longitudinal encounters with patients to contextualize the mechanistic basis of disease in a way that is not possible through traditional classroom learning. In addition to these formal activities, the MRSP also provides ongoing mentoring to all MRSP trainees regarding selection of a thesis research laboratory and assembly of the dissertation committee to support the goal of the NIGMS Molecular Medicine program to provide training in the basic biomedical sciences with a focus on elucidating the mechanisms of human disease. Based on the great demand for admission into the MRSP by outstanding training-grant-eligible students already admitted to Yale's umbrella biomedical sciences PhD program, we are requesting an increase in the number of annual slots from four to six, which would allow us to support three second-year and three third-year students each year.