Center for Molecular Epidemiology

摘要 流行病学领域在研究界日益突出，并成为一种 2020年家喻户晓的词汇。流行病学为揭示人类疾病的根本原因提供了工具 并反过来为临床实践和预防策略提供信息，就政策和监管行动提供建议，以及 推动科学进步向前发展。在第一和第二阶段，我们的生物医学研究卓越中心 达特茅斯(Cobre)分子流行病学中心有效地推进了该领域的研究。AS 新英格兰北部唯一的分子流行病学中心，也是仅有的科布雷项目之一 在全国范围内，我们成功地招募和指导了下一代独立的 职业生涯早期的调查员。我们进一步支持老牌研究人员扩大他们的研究项目， 形成新的合作，整合最新的生物医学发现、创新和方法。在此过程中， 我们极大地提高了研究生产率和拨款组合，这从 自我们科布雷中心成立以来，获得的出版物、演示文稿和赠款的数量。作为一部分 为了实现可持续发展，我们成立了新的流行病学系，并开发了创新的交叉 纪律培训补助金。 我们的凝聚力中心汇集了才华横溢的研究人员，专注于应用新的科学发现 和技术以解决主要的人类健康问题，2)确定疾病的早期指标 发病机制，以及3)探索人类群体中疾病病因和进展的共同途径， 包括与健康不平等有关的问题。在这个第三阶段的应用中，我们将使我们的分子 流行病学研究基础设施正朝着完全独立和可持续的方向发展。具体地说，我们将1) 发展最先进的生物库和生物质学资源设施核心，以提供关键的 响应生物医学科学家当前和未来需求的服务，2)扩展 有才华的、多样化的分子流行病学家，并提供必要的指导、职业发展和 培养尖端研究和使研究人员在NIH资金方面具有竞争力的研究资源，以及 3)加强治理结构、执行方法、利益攸关方参与和评估 这将加强我们中心的影响力，促进其战略愿景，并与区域和国家建立联系 合伙人。我们在第一阶段和第二阶段取得的成功，加上强有力的机构支持，使我们能够成为 新英格兰北部分子流行病学的重要资源，科布雷和IDEA网络 生物医学研究卓越(INBRE)计划，以及更广泛的。

ABSTRACT The field of epidemiology has gained increasing prominence in the research community and became a household word in 2020. Epidemiology provides the tools to uncover the underlying causes of human illness and to, in turn, inform clinical practice and preventive strategies, advise policy and regulatory actions, and move scientific advancements forward. In Phases I and II, our Centers of Biomedical Research Excellence (COBRE) Center for Molecular Epidemiology at Dartmouth has effectively advanced research in the field. As the only Center for molecular epidemiology in northern New England and one of the only COBRE programs with this focus nationally, we have successfully recruited and mentored the next generation of independent early career investigators. We further supported established investigators to enlarge their research programs, form new collaborations and integrate the latest biomedical discoveries, innovations, and methods. In doing so, we dramatically grew our research productivity and grant portfolio, as evidenced by the steep rise in the number of publications, presentations, and grants awarded since the inception of our COBRE Center. As part of achieving sustainability, we formed a new Department of Epidemiology and developed innovative cross- disciplinary training grants. Our cohesive Center brings together talented investigators focusing on 1) applying new scientific discoveries and technologies to address major human health concerns, 2) identifying early indicators of disease pathogenesis, and 3) exploring common pathways of disease etiology and progression in human populations, including those related to health inequities. In this Phase III application, we will progress our molecular epidemiology research infrastructure forward to full independence and sustainability. Specifically, we will 1) evolve a state-of-the-art Biorepository and Biospecimen Resource Facility Core that supplies the critical services responsive to the ongoing and future needs of biomedical scientists, 2) expand the pipeline of talented, diverse molecular epidemiologists, and provide the requisite mentorship, career development, and research resources to cultivate cutting-edge research and make investigators competitive for NIH funding, and 3) enhance the governance structure, implementation approaches, stakeholder engagement, and evaluation that will strengthen our Center’s impact, promote its strategic vision, and forge ties with regional and national partners. Our success in Phases I and II, combined with strong institutional support, positions us to serve as a vital resource in molecular epidemiology for Northern New England, for COBRE and IDeA Networks of Biomedical Research Excellence (INBRE) programs, and more broadly.