PRENATAL ALCOHOL EXPOSURE: LONG-TERM OUTCOMES

描述（由申请人提供）：这是一份针对项目公告PA-01-140的二次数据分析提案。产妇保健做法和儿童发展项目提供了一个独特的机会，以评估出生前接触酒精的儿童的生长和发育。参与该项目的妇女在产前第四个月和第七个月接受了采访。在婴儿出生时、8个月和18个月、3岁、6岁、10岁、14岁和16岁时对妇女及其子女进行评估。该队列从产前诊所选择，一半是白人，一半是非洲裔美国人。这一队列中的妇女代表了怀孕期间饮酒的整个范围。在每个阶段，我们测量了人口统计学状况，心理，社会和家庭环境，母亲和父亲的物质使用，以及家庭中男性伴侣的物质使用。我们评估了孩子们的认知、行为、学业和身体状况。在10岁、14岁和16岁时，我们有额外的青春期成熟度、神经心理状态、认知和行为发展、情感、学习成绩、精神状态、犯罪行为、物质使用以及他们朋友的物质使用。16年的评估没有用于分析酒精数据。 在拟议的分析中，我们将确定16岁时产前酒精暴露的影响。此外，我们将把这项评估与之前的阶段相结合，并在研究的多个时间点评估这些儿童的生长和发育。在16年，我们将评估酒精和其他物质使用障碍，精神疾病，犯罪，行为，社会和学术问题的发展。我们将评估产前酒精暴露对这些结果的影响。目前没有一项关于青少年物质使用和滥用的发病或病程的研究纳入了产前酒精暴露影响的识别，也没有胎儿酒精文献考虑了物质使用的发病和病程。这项建议将整合这些研究领域。

DESCRIPTION (provided by applicant): This is a proposal for a secondary data analysis in response to a Program Announcement: PA-01-140. The Maternal Health Practices and Child Development Project provides a unique opportunity to assess the growth and development of children who were prenatally exposed to alcohol. The women in this project were interviewed during their fourth and seventh prenatal months. Women and their offspring were assessed at the child's birth, 8 and 18 months, 3, 6, 10, 14, and 16 years of age. The cohort was selected from a prenatal clinic and is half Caucasian and half African-American. The women in this cohort represent the entire spectrum of alcohol use during pregnancy. At each phase, we measured demographic status, the psychological, social, and household environment, maternal and paternal substance use, and the substance use of the male partner in the household. We assessed the children's cognitive, behavioral, academic, and physical status. At ages 10, 14, and 16, we have additional measures of pubertal maturity, neuropsychological status, cognitive and behavioral development, affect, academic performance, psychiatric status, delinquent behaviors, substance use, and the substance use of their friends. The 16-year assessment was not funded for the analysis of the alcohol data. In the proposed analyses, we will identify the effects of prenatal alcohol exposure at age 16. In addition, we will integrate this assessment with the prior phases, and assess the growth and development of these children across the multiple time points of the study. At 16 years, we will evaluate the development of alcohol and other substance use disorders, psychiatric disorders, delinquency, behavior, and social and academic problems. We will assess the effects of prenatal alcohol exposure on these outcomes. None of the current research on the onset or course of adolescent substance use and abuse has incorporated the identification of the effects of prenatal alcohol exposure, nor has the fetal alcohol literature considered the onset and course of substance use. This proposal will integrate these areas of research.