Molecular basis for the efficient processing of antigens taken up by Clec9A, a DAMP receptor on dendritic cells

免疫系统的树突状细胞（DC）利用特定的受体来感知来自环境的危险信号。我们发现了一种DC危险受体Clec9A，它能识别并诱导对“危险”死细胞的免疫。感染细胞或死亡的肿瘤细胞。我们将研究DC如何使用Clec9A处理“危险的”死细胞，以及控制这种免疫反应效力的因素。这将使我们能够开发针对传染病和癌症的新型免疫疗法。

Dendritic cells (DC) of the immune system utilise specific receptors to sense danger signals from their environment. We identified a DC danger receptor, Clec9A, which recognizes and induces immunity to “dangerous” dead cells eg. infected cells or killed tumour cells. We will investigate how DC use Clec9A to process “dangerous” dead cells, and the factors that control the potency of this immune response. This will enable us to develop novel immunotherapies for infectious diseases and cancer.