RESTING STATE BRAIN ACTIVITY IN CHIMPANZEES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 PET和MRI已经被用来监测清醒但休息的受试者大脑的功能活动。这些研究表明，当受试者参与社会认知任务和自省时，某些已知的皮质区域会被激活。我们可以使用FDG-PET监测黑猩猩静止的认知大脑活动。当动物在家中休息时，口服FDG；在适当的摄取期后，动物被麻醉并接受PET扫描。 我们的结果表明，黑猩猩和人类在休息时激活了许多相同的皮质区域，特别是参与社会判断和个人记忆记忆的内侧额叶和内侧顶叶/后扣带回区域。然而，只有人类在与语言有关的额叶和颞顶区域表现出左侧化活动。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. PET and MRI have been used to monitor functional activity of the human brain in subjects awake, but at rest. These studies have demonstrated that certain cortical regions known to be activated when subjects engage in social cognition tasks and introspection. We can monitor resting cognitive brain activity in chimpanzees using FDG-PET. FDG is administered orally while the animal is resting in its home enclosure; after an appropriate uptake period, the animals is anesthetized and given a PET scan. Our results indicate that chimpanzees and humans activate many of the same cortical areas at rest, specifically, the medial frontal and medial parietal/posterior cingulate areas involved in social judgement and recollection of personal memories. Only humans, however, show left-lateralized activity in frontal and temporoparietal regions associated with language.