NEURAL CONTROL OF VISUAL VESTIBULAR BEHAVIOR

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 正常的姿势、平衡和稳定的视力取决于视觉和前庭系统之间的相互作用。 我们的研究旨在确定正常的视觉-前庭-眼神经行为的神经基质。由于前庭系统的正常发育或损伤，一直需要校准前庭眼反射的运动输出。 如果没有这种校准，在运动过程中保持平衡和清晰的视觉将出现困难。 除了长期的校准，视觉还受到每时每刻或动态视觉-前庭相互作用的支持。 我们最近已经证明，在MST和FEF的神经元有不同的贡献，以获得控制在意志性凝视运动。 我们使用目标扰动来证明FEF中的神经元在跟踪过程中对目标扰动比MST中的神经元更敏感。我们正在努力揭示支持注视控制的皮质-脑桥-小脑通路的不同组成部分中处理的信号。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Normal posture, balance and stable vision are dependent on interactions between the visual and vestibular systems. Our studies are directed at defining the neural substrate for normal visual-vestibular-oculomotor behavior. There is a continuous need to calibrate the motor output of the vestibular ocular reflex due to normal development or injury to the vestibular system. Without this calibration, difficulties in maintaining balance and clear vision during locomotion would occur. In addition to long-term calibration, vision is supported by moment-by-moment or dynamic visual-vestibular interactions. We have recently demonstrated that neurons in MST and FEF have differential contributions to gain control during volitional gaze movements. We used target perturbation to demonstrate the neurons in the FEF are more sensitive to target perturbation during tracking then those neurons MST. We are working to uncover the signals processed in different components of the cortical-ponto-cerebellar pathways supporting gaze control.