HYPERGRAVITY RESISTANCE TRAINING: COUNTERMEASURE TO MICROGRAVITY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 航天对各种生理系统的影响显然是深刻的，尽管进行了广泛的研究，但尚未完全了解。 空间界和科学界普遍认识到，即使短时间暴露在微重力下也会造成前庭功能障碍、肌肉力量和功能丧失以及直立耐力丧失。 因此，人们对在较长时间的太空飞行（例如前往火星）期间可能发生的生理失调感到相当担忧。 在这方面，已经制定了若干反措施，但似乎没有一项措施是完全有效的。 因此，NASA的生物医学研究和对策计划（NRA-03-OBPR-04）的一个优先项目是确定人工重力作为对策的潜在有用性，特别是在骨骼肌萎缩和肌肉功能丧失方面。 正如Burton所指出的（15、16），应对微重力的最明显的对策是离心机，但对它的探索却最少。 有一些明显的应用人造重力作为对抗微重力的措施。 例如，人造重力可用于对心血管系统施加立位挑战，可能防止因微重力而发生的立位耐力丧失。 人工重力在微重力环境中也有一些不那么明显的潜在应用。 例如，微重力环境中的人工重力/超重力可用作在高负荷条件下进行阻力训练的新方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The effects of spaceflight on various physiological systems are clearly profound, and despite extensive research are incompletely understood. It is widely recognized, within both the space and scientific communities, that even short periods of exposure to microgravity can produce vestibular dysfunction, losses in muscle strength and function, and loss of orthostatic tolerance. Hence, there is a substantial amount of concern regarding the physiological deconditioning that might occur during longer duration spaceflights, for instance to Mars. Within this context, several countermeasures have been developed, but none appear to be completely effective. Therefore, a program priority of NASA's Biomedical Research and Countermeasures Program (NRA-03-OBPR-04) is to determine the potential usefulness of artificial gravity as a countermeasure, especially with respect to skeletal muscle atrophy and loss of muscle function. As Burton noted (15,16), the most obvious countermeasure to microgravity is a centrifuge, yet it has been the least explored. There are some obvious applications of artificial gravity as a countermeasure to microgravity. For instance, artificial gravity could be used to impose orthostatic challenges on the cardiovascular system, possibly preventing the loss of orthostatic tolerance that occurs as a result of microgravity. There are also some potential applications of artificial gravity in a microgravity environment that are not as obvious. As an example, artificial gravity/hypergravity in a microgravity environment could be used as a novel method of performing resistance training under high loading conditions.