Center for Molecular, Cellular, and Translational Immunology

基于最初的10年期奖励的成功，此次Cobre续签申请的最终目标是 在达特茅斯完成全国公认的分子、细胞和蛋白质研究中心的建立 翻译免疫研究，并将这个科布雷免疫研究中心过渡到 (Cobre-CIR)在五年内成为一个基于基础设施的、独立的(来自Cobre资金)、可持续的中心 好几年了。随着长期免疫学项目的建立，该项目现在已经基本上 在Cobre支持的支持下，该提案利用了高度交互的协作核心 达特茅斯医学院(DMS)和达特茅斯希区柯克医学中心(DHMC)的教师。有了这个 扩大调查人员基础，第三阶段科布雷奖将提供资源，以建立所需的 基础设施，以支持Cobre-CIR，进一步发展该计划，并促进跨学科基础 从科学到转化性免疫研究。此基础设施将包括继续指导的 发展我们的免疫学能力，特别是那些以前得到科布雷支持的研究人员； Cobre核心的扩展及其与现有补充核心和共享核心的充分整合 DMS/DHMC的服务，特别是诺里斯棉花癌中心和其他免疫学和“肺” 达特茅斯大学和佛蒙特州大学的“生物学”和一个增强的试点项目 以指导、协作和/或翻译/人类系统研究为目标。与.一起 DMS/DHMC的实质性机构承诺，有信心现有的强大干部 已经被科布雷机制扩展和成熟的调查人员可以进一步发展到 完成可持续免疫研究中心的形成，该中心的基础是卓越的 基础科学研究，采用翻译方法促进双向床边 应用假设驱动的研究，并具有地区性影响，如果不是全国性的影响。

Based on the success ofthe initial 10-year award, the ultimate goals of this COBRE renewal application are to complete the establishment at Dartmouth of a nationally recognized Center for Molecular, Cellular, and Translational Immunological Research, and to transition this COBRE Center for Immunological Research (COBRE-CIR) to an infrastructure-based, freestanding (from COBRE funding), sustainable center in five years. With the foundation of a long-standing Immunology Program, which has now been substantially enhanced by COBRE support, this proposal takes advantage of a highly interactive core of collaborative faculty at Dartmouth Medical School (DMS) and Dartmouth Hitchcock Medical Center (DHMC). With this expanded investigator base, a Phase III COBRE award will provide the resources to build the needed infrastructure to sustain the COBRE-CIR, further grow the Program, and facilitate inter-disciplinary basic science to translational immunological research. This infrastructure will include the continued mentored development of our immunlogical faculty, especially those investigators previously supported by COBRE; expansion ofthe COBRE Cores and their full integration with existing complementary cores and shared services at DMS/DHMC, particularly the Norris Cotton Cancer Center and the other Immunology and "Lung Biology" COBREs at Dartmouth and the Univesrity of Vermont; and an enhanced Pilot Projdect Program with targeting to mentored, collaborative, and/or translational/human systems research. Together with substantive Institutional commitment by DMS/DHMC, there is confidence that the strong existing cadre of investigators, already expanded and matured by the COBRE mechanism, can be further developed to complete the formation of a sustainable Center for Immunological Research that is grounded in excellent basic science investigation, embraces a translational approach to promote bidirectional bench-to-bedside application of hypothesis-driven research, and has a regional, if not also national, impact.