Bioenergetic and Cardiometabolic Consequences of the Loss of Gonadal Function

科罗拉多性别差异和女性健康卓越研究专门中心（SCORE） 主要研究性腺功能丧失的生物能量和心脏代谢后果。的 SCORE的首要科学目标是解决性腺衰老对人类生殖系统的影响方面的知识空白。 能量稳态和代谢的调节，通过进行机械驱动的研究， 基础到临床的转化谱。科学的前提是，性腺老化，通过 伴随着性激素的下降，介导了增加慢性疾病风险的生物变化。 重要的是，由于性腺衰竭在中年女性中是不可避免的，但在男性中很少见，直到生命的后期， 这符合SCORE计划研究影响妇女健康的性别差异的目标。的 科罗拉多评分关注腹部脂肪堆积倾向的增加以及相关的 心脏代谢功能障碍是卵巢功能丧失的结果。总体教育 目标是让新的研究人员参与与SCORE重点一致的研究。分数会 提供指导性的职业发展和培训，指导如何进行研究， 性别作为生物学变量（SABV）。这些总体目标将通过以下方式实现： 目的：1）推进新的翻译研究的机制，假设有助于 腹部肥胖和心脏代谢功能障碍，这些症状在雌二醇停药后加速。所有项目 包括对犬尿氨酸途径的关注，因为有新的证据表明它调节能量， 体内平衡、代谢功能和衰老过程。科罗拉多SCORE的调查人员是 这些领域，并非常有利于推进这项研究。2)吸引和支持优秀人才 具有与SCORE相关研究兴趣的早期职业调查员，并让他们参与CEC培训 这些活动将成功地推动他们的职业生涯。SCORE将支持一名学者和四名飞行员 每年的获奖项目。3)为SCORE研究项目，学者， 通过拉丁美洲和加勒比地区，包括生物统计，数据管理，财务监督， 行政支援4)与CU-AMC的其他计划合作并利用其提供的资源 （多学科老龄化中心，卢德曼妇女健康研究中心，营养肥胖研究 中心，临床和转化科学研究所），以提高知名度和多学科的影响力， 妇女健康研究和调查SABV的重要性。活动将针对科学和非专业人士 地方、区域和国家各级的社区。实现这些目标将把SCORE定位为 妇女健康研究的国家领导人，CEC作为培训下一个 这将有助于培养一代科学家，将SABV纳入其研究，以改善妇女健康。

The Colorado Specialized Center of Research Excellence (SCORE) on Sex Differences and Women’s Health is focused on Bioenergetic and Cardiometabolic Consequences of the Loss of Gonadal Function. The overarching scientific goal of the SCORE is to address gaps in knowledge of the impact of gonadal aging on the regulation of energy homeostasis and metabolism by conducting mechanistically driven research across the basic-to-clinical translational spectrum. The scientific premise is that gonadal aging, through the accompanying decline in sex hormones, mediates biological changes that increase risk for chronic disease. Importantly, because gonadal failure is inevitable in women in mid-life, but rare in men until much later in life, this meets the objective of the SCORE Program to study sex differences that impact women’s health. The Colorado SCORE is focused on the increased propensity for abdominal fat accumulation and the associated cardiometabolic dysfunction that are consequent to the loss of ovarian function. The overarching educational objective is to engage new investigators in research aligned with the focus of the SCORE. The SCORE will provide mentored career development and training on how to conduct research that appropriately addresses sex as a biological variable (SABV). These overarching objectives will be accomplished through the following Aims: 1) Advance novel translational research on mechanisms that are postulated to contribute to the abdominal adiposity and cardiometabolic dysfunction that accelerate following estradiol withdrawal. All projects include a focus on the kynurenine pathway because of the emerging evidence that it regulates energy homeostasis, metabolic function, and the aging process. The Colorado SCORE investigators are experts in these areas and are exceptionally well positioned to advance this research. 2) Attract and support outstanding early career investigators with research interests related to the SCORE and engage them in CEC training activities that will successfully advance their careers. The SCORE will support one Scholar and four Pilot Project Awardees each year. 3) Provide infrastructural support for the SCORE Research Projects, Scholars, and Pilot Awardees through the LAC, including biostatistics, data management, financial oversight, and administrative support. 4) Partner with and leverage resources provided by other programs at CU-AMC (Multidisciplinary Center on Aging, Ludeman Center for Women’s Health Research, Nutrition Obesity Research Center, Clinical and Translational Sciences Institute) to elevate the visibility and multi-disciplinary reach of women’s health research and the importance of investigating SABV. Activities will target both scientific and lay communities at local, regional, and national levels. Achieving these Aims will position the SCORE as a national leader in women’s health research, and the CEC as a model program for training the next generation of scientists to integrate SABV in their research with a goal of improving women’s health.